Evidence map›Paper›PMID 30746447›Full record

ArticleScience advances2019

Stephen S Dominy, Casey Lynch, Florian Ermini, Malgorzata Benedyk, Agata Marczyk, Andrei Konradi, Mai Nguyen, Ursula Haditsch, Debasish Raha, Christina Griffin and 16 more

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1,112 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,112citing papers in PubMed, 7 pooled it
114.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05549648 nacompletednot on this mapstarted 2022, after this paper: background citation

Artificial Intelligence-Based APP for Home Oral Muscles Exercises for Healthy Adults

TypeinterventionalSponsorThe University of Hong KongRan2022 to 2023Enrolled92ConditionsOral ManifestationsArmsHome oral excrise
NCT05557617 unknown statusnot on this mapstarted 2020, after this paper: background citation

The Role of Periodontitis and Periodontal Bacteria in Development of Dementia

TypeobservationalSponsorRegion Örebro CountyRan2020 to 2024Enrolled120ConditionsAlzheimer Disease, Dementia, Periodontitis
3 · Its place in the literature

Who cites it

1,112 citing papers in PubMed, 7 syntheses or guidelines pooled it, 1,780 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. The microbiota-proteostasis axis: implications in neurodegenerative diseases.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review

1,052 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 8 institutions in 5 countries.

Stephen S DominyCortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.ORCID 0000-0002-0816-9658
Casey LynchCortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.
Florian ErminiCortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.ORCID 0000-0002-0176-8180
Malgorzata BenedykDepartment of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Agata MarczykDepartment of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Andrei KonradiCortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.
Mai NguyenCortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.ORCID 0000-0003-4304-4380
Ursula HaditschCortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.ORCID 0000-0003-4799-5044
Debasish RahaCortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.
Christina GriffinCortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.
Leslie J HolsingerCortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.
Shirin Arastu-KapurCortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.
Samer KabaCortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.
Alexander LeeCortexyme, Inc., 269 East Grand Ave., South San Francisco, CA, USA.
Mark I RyderDivision of Periodontology, Department of Orofacial Sciences, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-8540-4017
Barbara PotempaDepartment of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA.ORCID 0000-0002-1226-6952
Piotr MydelDepartment of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Annelie HellvardMalopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland.
Karina AdamowiczDepartment of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
Hatice HasturkThe Forsyth Institute, Cambridge, MA, USA.
Glenn D WalkerCooperative Research Centre for Oral Health Science, Melbourne Dental School and the Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0001-5289-9810
Eric C ReynoldsCooperative Research Centre for Oral Health Science, Melbourne Dental School and the Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-6618-4856
Richard L M FaullDepartment of Anatomy with Radiology, Centre for Brain Research and NeuroValida, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Maurice A CurtisCentre for Brain Research and NeuroValida, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Mike DragunowCentre for Brain Research and NeuroValida, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Jan PotempaDepartment of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.ORCID 0000-0002-3600-7461
Diazyme (United States) · USJagiellonian University · PLThe University of Melbourne · AUUniversity of Auckland · NZBrain Research New Zealand · NZHarvard University · USUniversity of California, San Francisco · USUniversity of Louisville · US

Funding

Bacterial peptidylarginine deiminase, a link between gums and joint diseaseR01DE022597 · NIDCR · UNIVERSITY OF LOUISVILLE · PI POTEMPA, JAN S · 2013 to 2023
$3.7M
NIDCR NIH HHS R01 DE022597
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgedAlzheimer DiseaseAmyloid beta-PeptidesAnimalsBacteroidaceae InfectionsBrainCell Line, TumorDisease Models, AnimalFemaleGingipain Cysteine EndopeptidasesHumansMaleMiceMice, Inbred BALB CMiddle AgedNeuroprotective AgentsAmyloid beta-Peptidesamyloid beta-protein (1-42)Gingipain Cysteine EndopeptidasesMAPT protein, humanNeuroprotective AgentsPeptide FragmentsSmall Molecule Librariestau Proteins

Identifiers

PMID30746447
PMCPMC6357742
OpenAlexW2912555658

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.