ArticleScience advances2019
High-throughput label-free molecular fingerprinting flow cytometry.
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Microfluidic Light-Scattering Imaging Coupled with Deep Learning for Label-Free Single-Cell Classification of Lymphoma Cells.Biosensors · 2026Article
- Sustainable production of glutaric acid in microbial cell factories: Current advances and future prospects.Synthetic and systems biotechnology · 2026Review
- Structural, Compositional, and Dielectric State Profiling in Label-Free Single-Cell Monitoring.Small methods · 2026Review
- Mid-infrared snapshot spectral imaging via nonlinear radial dispersion.Nature communications · 2026Article
- Raman spectroscopy combined with multiple technologies for label-free identification of immune cells: An overview.Journal of pharmaceutical analysis · 2026Review
- The Next Frontier in Vibrational Imaging: Chemically Designed Raman Probes Pass the Spectral Barrier.JACS Au · 2026Review
- Rapid-manufacturing and cost-effective single-layer microfluidic device for high-throughput three-dimensional hydrodynamic focusing.Microsystems & nanoengineering · 2026Article
- Unveiling aging heterogeneities in human dermal fibroblasts via nanosensor chemical cytometry.Nature communications · 2025Article
- High-throughput single-cell sorting by stimulated Raman-activated cell ejection.Science advances · 2024Article
- Multicolor iLIFE (m-iLIFE) volume cytometry for high-throughput imaging of multiple organelles.Scientific reports · 2024Article
- Label-free live cell recognition and tracking for biological discoveries and translational applications.Npj imaging · 2024Review
- Deciphering the aging process through single-cell cytometric technologies.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2024Review
- Raman micro-spectroscopy as a tool to study immunometabolism.Biochemical Society transactions · 2024Review
- Raman Flow Cytometry and Its Biomedical Applications.Biosensors · 2024Review
- Wide-field mid-infrared hyperspectral imaging beyond video rate.Nature communications · 2024Article
- DNA framework signal amplification platform-based high-throughput systemic immune monitoring.Signal transduction and targeted therapy · 2024Article
- Raman cell sorting for single-cell research.Frontiers in bioengineering and biotechnology · 2024Review
- Robust real-time estimation of non-uniform angular velocity and sub-pixel jitter in images captured with resonant scanners.Optics express · 2023Article
- High-throughput single-cell sorting by stimulated Raman-activated cell ejection.bioRxiv : the preprint server for biology · 2023Article
- Toward Gene-Correlated Spatially Resolved Metabolomics with Fingerprint Coherent Raman Imaging.The journal of physical chemistry. B · 2023Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flow cytometry is an indispensable tool in biology for counting and analyzing single cells in large heterogeneous populations. However, it predominantly relies on fluorescent labeling to differentiate cells and, hence, comes with several fundamental drawbacks. Here, we present a high-throughput Raman flow cytometer on a microfluidic chip that chemically probes single live cells in a label-free manner. It is based on a rapid-scan Fourier-transform coherent anti-Stokes Raman scattering spectrometer as an optical interrogator, enabling us to obtain the broadband molecular vibrational spectrum of every single cell in the fingerprint region (400 to 1600 cm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.