Evidence map›Paper›PMID 30746336›Full record

ArticleJournal of reproduction & infertility

The Study of Association Between Polymorphism of TNF-α Gene's Promoter Region and Recurrent Pregnancy Loss.

Roshanak Aboutorabi, Ehsan Behzadi, Mohammad Javad Sadegh, Seyed Pooriya Fatehi, Soroosh Semsarzadeh, Yasaman Zarrin, Mohammad Kazemi, Laleh Rafiee, Fatemeh Sadat Mostafavi

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PubMed Full text at PMC
In one paragraph

Article in Journal of reproduction & infertility. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Genetics of recurrent pregnancy loss among Iranian population.Molecular genetics & genomic medicine · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Roshanak AboutorabiInfertility Laboratory, Beheshti Hospital, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Ehsan BehzadiSchool of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Mohammad Javad SadeghSchool of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Seyed Pooriya FatehiSchool of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Soroosh SemsarzadehSchool of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Yasaman ZarrinSchool of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Mohammad KazemiDepartment of Genetics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Laleh RafieeApplied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Fatemeh Sadat MostafaviInfertility Laboratory, Beheshti Hospital, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccording to the literature review, polymorphisms of tumor necrosis factor alpha's (TNF-α) promoter region are probably the genetic risk factors of recurrent pregnancy loss. This study has investigated five single nucleotide polymorphisms in the TNF-α gene's promoter region to evaluate their relationship with recurrent pregnancy loss disorder.

methodsBlood samples were taken from 65 women with recurrent pregnancy loss (Case group) and 65 healthy women with a history of successful pregnancy (Control group). Polymerase chain reaction with high resolution melting (PCR-HRM) analysis was done to determine the promoter region of -308G/A, -850T/C, -238G/A, -1031T/C and -863A/C TNF-α polymorphisms. The data were assessed using logistic regression models. P values less than 0.05 were considered statistically significant.

resultsSignificant associations were found between recurrent pregnancy loss and -863C/A (p=0.000), -308G/A (p=0.045), and -238G/A (p=0.034) polymorphisms. TNF-α polymorphisms of -863C and -238G may be susceptible factors of recurrent pregnancy loss cases. The -308G polymorphism has an important role in maintaining pregnancy.

conclusionThe -863C/A and -238G/A TNF-α polymorphisms are possible genetic risk factors of recurrent pregnancy loss and might be its predictive markers.

Indexed as

PolymorphismRecurrent pregnancy lossTumor necrosis factor alpha

Identifiers

PMID30746336
PMCPMC6328976
OpenAlexW2900125047

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.