ArticleJournal of thoracic disease2018
Impact of intercostal nerve blocks using liposomal versus standard bupivacaine on length of stay in minimally invasive thoracic surgery patients.
Article in Journal of thoracic disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 58 citations in OpenAlex.
- Liposomal Bupivacaine in Perioperative Analgesia: A Comprehensive Review of Clinical Efficacy, Safety, and Economic Context.Current pain and headache reports · 2026Review
- Thoracic paravertebral block with liposomal bupivacaine versus ropivacaine for postoperative analgesia in thoracic surgery: a randomized controlled study.Journal of thoracic disease · 2026Article
- Liposomal bupivacaine in thoracic surgery: a comprehensive review of current evidence and clinical implications.Frontiers in medicine · 2026Review
- Effect of Liposomal Bupivacaine for Intercostal Nerve Block on Chronic Postoperative Pain Following Video-Assisted Thoracoscopic Lung Resection: A Retrospective Cohort Study.Drug design, development and therapy · 2026Article
- Are there different phenotypes of thoracic surgery patients? A latent class analysis of pretreatment patient-reported outcomes.JTCVS open · 2025Article
- Effect of preoperative thoracic paravertebral block using liposomal bupivacaine combined with drainage-tube patient-controlled analgesia on postoperative pain after thoracoscopic lobectomy: a prospective, multicentre, double-blind, randomized controlled study protocol.Perioperative medicine (London, England) · 2025Article
- Article
- Liposomal bupivacaine intercostal block placed under direct vision reduces morphine use in thoracic surgery.Journal of thoracic disease · 2024Article
- The Efficacy of Liposomal Bupivacaine in Thoracic Surgery: A Systematic Review and Meta-Analysis.Journal of pain research · 2024Review
- Effect of liposomal bupivacaine for preoperative erector spinae plane block on postoperative pain following video-assisted thoracoscopic lung surgery: a protocol for a multicenter, randomized, double-blind, clinical trial.Frontiers in medicine · 2024Article
- Efficacy of serratus posterior superior intercostal plane block (SPSIPB) on post-operative pain and total analgesic consumption in patients undergoing video-assisted thoracoscopic surgery (VATS): A double-blinded randomised controlled trial.Indian journal of anaesthesia · 2023Article
- Expanding clinicians' armamentarium for regional pain control after thoracic surgery.Journal of thoracic disease · 2023Article
- Pain control after thoracic surgery begins in the operating room.Journal of thoracic disease · 2022Article
- The challenge of measuring post-operative pain reduction with opioid-sparing anesthetic techniques in video-assisted thoracoscopic surgery.Journal of thoracic disease · 2022Article
- Regional anesthesia and acute perioperative pain management in thoracic surgery: a narrative review.Journal of thoracic disease · 2022Review
- Intercostal nerve blockade with liposomal bupivacaine reduces length of stay after video assisted thoracic surgery (VATS) lobectomy.Journal of thoracic disease · 2022Article
- Osmotically balanced, large unilamellar liposomes that enable sustained bupivacaine release for prolonged pain relief in in vivo rat models.Scientific reports · 2021Article
- Liposomal bupivacaine for prolonging analgesia with TAP blocks-two steps forward, one step back.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2021Article
- [Comparison of the Clinical Effect of Uniportal Video-assisted Thoracoscopic Lobectomy and Biportal Video-assisted Thoracoscopic Lobectomy in the Treatment of Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2020Article
- Pre-emptive pain management program is associated with reduction of opioid prescription after minimally invasive pulmonary resection.Journal of thoracic disease · 2020Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostsurgical pain control can have a significant impact on patient outcomes and hospital-associated costs. We sought to evaluate the effect of intercostal nerve blocks using liposomal bupivacaine on length of stay (LOS) in patients undergoing video-assisted thoracoscopic surgery (VATS).
methodsWe retrospectively reviewed outcomes in 80 patients undergoing VATS wedge resection, VATS lobectomy, or minimally-invasive esophagectomy (MIE). Patients received either liposomal bupivacaine (n=40) or standard-release bupivacaine with epinephrine (n=40) via intercostal nerve block. The LOS, 24-hour postoperative pain scores, overall opioid usage, and patient ambulation rates at 24 hours were compared for the two groups.
resultsThe median LOS was significantly shorter in patients receiving liposomal bupivacaine, at 1.35 days (IQR, 1.28 to 1.53 days) compared to 2.45 days (IQR, 2.08 to 3.51 days) in patients receiving standard-release bupivacaine (P<0.0001). Average post-operative pain score during the first 24 hours was 3.4±1.8 for the liposomal bupivacaine group and 2.3±1.2 for the control group (P=0.002). This difference, though statistically significant, is likely not clinically significant, as there was no difference in 24-hour postoperative intravenous morphine equivalent usage between the liposomal bupivacaine and control groups (29.8±21.0
conclusionsThe use of liposomal bupivacaine is associated with decreased LOS in postoperative thoracic surgery patients and earlier return to ambulation. It does not, however, decrease 24-hour postoperative pain scores or opioid usage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.