Evidence map›Paper›PMID 30746157›Full record

ArticleCurrent health sciences journal

In Vitro Cytotoxicity of Zinc Fructoborate, a Novel Zinc-Boron Active Natural Complex.

C N Oancea, A Cîmpean, R Ion, J Neamţu, A Biţă, I R Scorei, A S Neamţu, O C Rogoveanu, S I Zaharie, G Birkenmeier

Abstract read
In one paragraph

Article in Current health sciences journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Zinc-Boron-PLGA biocomposite material: preparation, structural characterization, and in vitro assessment.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

C N OanceaPhD Student, Doctoral School, University of Medicine and Pharmacy of Craiova, Romania.
A CîmpeanDepartment of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, Romania.
R IonDepartment of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, Romania.
J NeamţuDepartment of Physics, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Romania.
A BiţăDepartment of Pharmacognosy & Phytotherapy, Faculty of Pharmacy,University of Medicine and Pharmacy of Craiova, Romania.
I R Scorei5Research Base of Boron Natural Compounds-BioBoron Institute, S.C. Natural Research S.R.L. Craiova, Romania.
A S NeamţuPhD Student, Doctoral School, University of Medicine and Pharmacy of Craiova, Romania.
O C RogoveanuDepartment of Medical Rehabilitation, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania.
S I ZaharieDepartment of Nephrology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania.
G BirkenmeierInstitute of Biochemistry, Faculty of Medicine, University of Leipzig, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, the role of zinc in biological systems has been a subject of intense research. Zinc is required for multiple metabolic processes as a structural, regulatory, or catalytic ion. The objective of this study, was to assess the toxicity profile of a newly synthesized zinc-boron molecule on cultured cells. Zinc fructoborate, at different levels of concentration, was tested for its impact on the Vero kidney cell line (ATCC® CCL-81™) using the MTT assay. The compound exhibited a low cytotoxic effect on the cell line. Thus, our study demonstrates that the zinc fructoborate could become a promising dietary supplement molecule.

Indexed as

ageingcytotoxicityin vitroMTT assayzinc fructoborate

Identifiers

PMID30746157
PMCPMC6320461

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.