Evidence map›Paper›PMID 30746138›Full record

ArticleClinical kidney journal2019

Twelve weeks of supervised exercise improves self-reported symptom burden and fatigue in chronic kidney disease: a secondary analysis of the 'ExTra CKD' trial.

Thomas J Wilkinson, Emma L Watson, Douglas W Gould, Soteris Xenophontos, Amy L Clarke, Barbara P Vogt, João L Viana, Alice C Smith

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical kidney journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Sleep-Related Disorders in Patients with CKD and Kidney Transplant Recipients.Clinical journal of the American Society of Nephrology : CJASN · 2025
    Review
  6. Article
  7. Systematic literature review and meta-analysis by Wahida et al. 2023.Journal of Taibah University Medical Sciences · 2025
    Article
  8. Insights into effective fatigue reducing interventions in kidney transplant candidates: a scoping review.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Five Things to Know About Pruritus in Patients on Dialysis.Canadian journal of kidney health and disease · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Thomas J WilkinsonDepartment of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.
Emma L WatsonDepartment of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.
Douglas W GouldDepartment of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.
Soteris XenophontosDepartment of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.
Amy L ClarkeDepartment of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.
Barbara P VogtDepartment of Clinical Medicine, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, UNESP, São Paulo, Brazil.
João L VianaSchool of Sport, Exercise and Health Sciences, Loughborough University, UK.
Alice C SmithDepartment of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.
University of Leicester · GBLeicester General Hospital · GBLoughborough University · GBUniversidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic kidney disease (CKD) patients experience a high symptom burden including fatigue, sleep difficulties, muscle weakness and pain. These symptoms reduce levels of physical function (PF) and activity, and contribute to poor health-related quality of life (HRQoL). Despite the gathering evidence of positive physiological changes following exercise in CKD, there is limited evidence on its effect on self-reported symptom burden, fatigue, HRQoL and physical activity.

methodsThirty-six patients [mean ± SD 61.6 ± 11.8 years, 22 (61%) females, estimated glomerular filtration rate: 25.5 ± 7.8 mL/min/1.73 m

resultsExercise reduced the total number of symptoms reported by 17% and had favourable effects on fatigue in both groups. AE reduced the frequency of 'itching', 'impotence' and 'shortness of breath' symptoms, and the intrusiveness for symptoms of 'sleep disturbance', 'loss of muscular strength/power', 'muscle spasm/stiffness' and 'restless legs'. The addition of resistance exercise in the CE group saw a reduction in 'loss of muscular strength/power'. No changes were seen in subjective PF or physical activity levels. AE increased self-efficacy for physical activity.

conclusionsSupervised exercise had favourable effects on symptom frequency and intrusiveness, including substantial improvements in fatigue. Although the intervention did not improve self-reported physical activity levels, AE increased patients' self-efficacy for physical activity. These favourable changes in self-reported outcomes support the important role of exercise in CKD.

Indexed as

chronic kidney diseaseexercisefatigue symptomshealth-related quality of life

Identifiers

PMID30746138
PMCPMC6366144
OpenAlexW2887885660

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.