Evidence map›Paper›PMID 30746088›Full record

ArticleChemical science2019

An enzyme-activatable probe liberating AIEgens: on-site sensing and long-term tracking of β-galactosidase in ovarian cancer cells.

Kaizhi Gu, Wanshan Qiu, Zhiqian Guo, Chenxu Yan, Shiqin Zhu, Defan Yao, Ping Shi, He Tian, Wei-Hong Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Turn-On Fluorescence Probe for Cancer-RelatedMolecules (Basel, Switzerland) · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Frontiers in chemistry · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kaizhi GuShanghai Key Laboratory of Functional Materials Chemistry , Key Laboratory for Advanced Materials and Institute of Fine Chemicals , Joint International Research Laboratory of Precision Chemistry and Molecular Engineering , Feringa Nobel Prize Scientist Joint Research Center , School of Chemistry and Molecular Engineering , East China University of Science & Technology , Shanghai 200237 , China . Email: guozq@ecust.edu.cn.
Wanshan QiuDepartment of Cardiothoracic Surgery , Children's Hospital of Fudan University , Shanghai 201102 , China.
Zhiqian GuoShanghai Key Laboratory of Functional Materials Chemistry , Key Laboratory for Advanced Materials and Institute of Fine Chemicals , Joint International Research Laboratory of Precision Chemistry and Molecular Engineering , Feringa Nobel Prize Scientist Joint Research Center , School of Chemistry and Molecular Engineering , East China University of Science & Technology , Shanghai 200237 , China . Email: guozq@ecust.edu.cn.ORCID 0000-0002-2192-825X
Chenxu YanShanghai Key Laboratory of Functional Materials Chemistry , Key Laboratory for Advanced Materials and Institute of Fine Chemicals , Joint International Research Laboratory of Precision Chemistry and Molecular Engineering , Feringa Nobel Prize Scientist Joint Research Center , School of Chemistry and Molecular Engineering , East China University of Science & Technology , Shanghai 200237 , China . Email: guozq@ecust.edu.cn.
Shiqin ZhuShanghai Key Laboratory of Functional Materials Chemistry , Key Laboratory for Advanced Materials and Institute of Fine Chemicals , Joint International Research Laboratory of Precision Chemistry and Molecular Engineering , Feringa Nobel Prize Scientist Joint Research Center , School of Chemistry and Molecular Engineering , East China University of Science & Technology , Shanghai 200237 , China . Email: guozq@ecust.edu.cn.
Defan YaoShanghai Key Laboratory of Functional Materials Chemistry , Key Laboratory for Advanced Materials and Institute of Fine Chemicals , Joint International Research Laboratory of Precision Chemistry and Molecular Engineering , Feringa Nobel Prize Scientist Joint Research Center , School of Chemistry and Molecular Engineering , East China University of Science & Technology , Shanghai 200237 , China . Email: guozq@ecust.edu.cn.
Ping ShiState Key Laboratory of Bioreactor Engineering , East China University of Science & Technology , Shanghai 200237 , China.ORCID 0000-0002-6904-2802
He TianShanghai Key Laboratory of Functional Materials Chemistry , Key Laboratory for Advanced Materials and Institute of Fine Chemicals , Joint International Research Laboratory of Precision Chemistry and Molecular Engineering , Feringa Nobel Prize Scientist Joint Research Center , School of Chemistry and Molecular Engineering , East China University of Science & Technology , Shanghai 200237 , China . Email: guozq@ecust.edu.cn.
Wei-Hong ZhuShanghai Key Laboratory of Functional Materials Chemistry , Key Laboratory for Advanced Materials and Institute of Fine Chemicals , Joint International Research Laboratory of Precision Chemistry and Molecular Engineering , Feringa Nobel Prize Scientist Joint Research Center , School of Chemistry and Molecular Engineering , East China University of Science & Technology , Shanghai 200237 , China . Email: guozq@ecust.edu.cn.ORCID 0000-0001-9103-166X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Development of fluorescent probes for on-site sensing and long-term tracking of specific biomarkers is particularly desirable for the early detection of diseases. However, available small-molecule probes tend to facilely diffuse across the cell membrane or remain at the activation site but always suffer from the aggregation-caused quenching (ACQ) effect. Here we report an enzyme-activatable aggregation-induced emission (AIE) probe QM-βgal, which is composed of a hydrophilic β-galactosidase (β-gal)-triggered galactose moiety and a hydrophobic AIE-active fluorophore QM-OH. The probe is virtually non-emissive in aqueous media, but when activated by β-gal, specific enzymatic turnover would liberate hydrophobic AIE luminogen (AIEgen) QM-OH, and then highly fluorescent nanoaggregates are

Identifiers

PMID30746088
PMCPMC6334664

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.