Evidence map›Paper›PMID 30746066›Full record

ArticleMedChemComm2018

Discovery of a 3,4,5-trisubstituted-1,2,4-triazole agonist with high affinity and selectivity at the somatostatin subtype-4 (sst

Iman Daryaei, Karin Sandoval, Ken Witt, Maria Kontoyianni, A Michael Crider

Abstract read
In one paragraph

Article in MedChemComm, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Iman DaryaeiDepartment of Pharmaceutical Sciences , School of Pharmacy , Southern Illinois University Edwardsville , Edwardsville , IL , 62026-2000 USA . Email: mcrider@siue.edu.ORCID 0000-0003-1384-2621
Karin SandovalDepartment of Pharmaceutical Sciences , School of Pharmacy , Southern Illinois University Edwardsville , Edwardsville , IL , 62026-2000 USA . Email: mcrider@siue.edu.
Ken WittDepartment of Pharmaceutical Sciences , School of Pharmacy , Southern Illinois University Edwardsville , Edwardsville , IL , 62026-2000 USA . Email: mcrider@siue.edu.
Maria KontoyianniDepartment of Pharmaceutical Sciences , School of Pharmacy , Southern Illinois University Edwardsville , Edwardsville , IL , 62026-2000 USA . Email: mcrider@siue.edu.
A Michael CriderDepartment of Pharmaceutical Sciences , School of Pharmacy , Southern Illinois University Edwardsville , Edwardsville , IL , 62026-2000 USA . Email: mcrider@siue.edu.ORCID 0000-0002-8638-7626

Funding

Lead optimization of somatostatin-based therapeutic for Alzheimer's DiseaseR01AG047858 · NIA · SOUTHERN ILLINOIS UNIV AT EDWARDSVILLE · PI WITT, KEN A · 2015 to 2019
$2.8M
NIA NIH HHS R01 AG047858
6 · The paper itself

Abstract

A series of compounds containing a 1,2,4-triazole moiety were synthesized, targeting the somatostatin receptor subtype-4 (sst

Identifiers

PMID30746066
PMCPMC6336083

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.