Evidence map›Paper›PMID 30745901›Full record

ArticleFrontiers in immunology2019

Conservation, Extensive Heterozygosity, and Convergence of Signaling Potential All Indicate a Critical Role for KIR3DL3 in Higher Primates.

Laura A Leaton, Jonathan Shortt, Katherine M Kichula, Sudan Tao, Neda Nemat-Gorgani, Alexander J Mentzer, Stephen J Oppenheimer, Zhihui Deng, Jill A Hollenbach, Christopher R Gignoux and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

  1. Frontiers in genetics · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. TheFrontiers in immunology · 2023
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Haplotype-Based Analysis ofFrontiers in immunology · 2020
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 3 countries.

Laura A LeatonDivision of Biomedical Informatics and Personalized Medicine, University of Colorado, Aurora, CO, United States.
Jonathan ShorttDivision of Biomedical Informatics and Personalized Medicine, University of Colorado, Aurora, CO, United States.
Katherine M KichulaDivision of Biomedical Informatics and Personalized Medicine, University of Colorado, Aurora, CO, United States.
Sudan TaoDivision of Biomedical Informatics and Personalized Medicine, University of Colorado, Aurora, CO, United States.
Neda Nemat-GorganiDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA, United States.
Alexander J MentzerWellcome Trust Centre for Human Genetics, and Jenner Institute, University of Oxford, Oxford, United Kingdom.
Stephen J OppenheimerInstitute of Social and Cultural Anthropology, School of Anthropology and Museum Ethnography, University of Oxford, Oxford, United Kingdom.
Zhihui DengImmunogenetics Laboratory, Shenzhen Blood Center, Shenzhen, China.
Jill A HollenbachDepartment of Neurology, University of California, San Francisco, San Francisco, CA, United States.
Christopher R GignouxDivision of Biomedical Informatics and Personalized Medicine, University of Colorado, Aurora, CO, United States.
Lisbeth A GuethleinDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA, United States.
Peter ParhamDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA, United States.
Mary CarringtonBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, United States.
Paul J NormanDivision of Biomedical Informatics and Personalized Medicine, University of Colorado, Aurora, CO, United States.
University of Colorado Anschutz Medical Campus · USStanford University · USUniversity of Colorado Denver · USCentre for Human Genetics · GBRagon Institute of MGH, MIT and Harvard · USShenzhen Blood Center · CNUniversity of California, San Francisco · USUniversity of Oxford · GB

Funding

Insights Into Immune-Related Diseases Born from Population GenomicsU01AI090905 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Paul John Norman · 2010 to 2026
$10.9M
KIR association studies in neurological diseasesU19NS095774 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERNANDEZ-VINA, MARCELO, OKSENBERG, JORGE R. · 2015 to 2019
$7.0M
STRUCTURAL BIOLOGY OF HLA-A,B ANTIGENSR01AI017892 · NIAID · STANFORD UNIVERSITY · PI PARHAM, PETER R · 1985 to 2019
$6.1M
CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENIAID NIH HHS R01 AI017892NIAID NIH HHS U01 AI090905NINDS NIH HHS U19 NS095774
6 · The paper itself

Abstract

Natural killer (NK) cell functions are modulated by polymorphic killer cell immunoglobulin-like receptors (KIR). Among 13 human

Indexed as

HeterozygoteSignal TransductionAmino Acid SequenceAnimalsBiological EvolutionHominidaeHumansKiller Cells, NaturalModels, MolecularPhylogeographyPrimatesProtein BindingProtein ConformationProtein Interaction Domains and MotifsReceptors, KIRSelection, GeneticKIR3DL3 protein, humanReceptors, KIRcomparative evolutionHLA class Iinfectious diseaseKIRKIR3DL3NK cellsreproduction

Identifiers

PMID30745901
PMCPMC6360152
OpenAlexW2914682751

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.