Evidence map›Paper›PMID 30745881›Full record

ReviewFrontiers in physiology2019

Effect of Exercise on Fatty Acid Metabolism and Adipokine Secretion in Adipose Tissue.

Adriana Mika, Filippo Macaluso, Rosario Barone, Valentina Di Felice, Tomasz Sledzinski

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 4 pooled it
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 4 syntheses or guidelines pooled it, 183 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. ZumbaInternational journal of environmental research and public health · 2020
    Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Article
  11. Article
  12. Physical exercise in liver diseases.Hepatology (Baltimore, Md.) · 2026
    Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Adriana MikaDepartment of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Gdańsk, Gdańsk, Poland.
Filippo MacalusoDepartment of Biomedicine, Neurosciences, and Advanced Diagnostic (Bi.N.D.), University of Palermo, Palermo, Italy.
Rosario BaroneDepartment of Biomedicine, Neurosciences, and Advanced Diagnostic (Bi.N.D.), University of Palermo, Palermo, Italy.
Valentina Di FeliceDepartment of Biomedicine, Neurosciences, and Advanced Diagnostic (Bi.N.D.), University of Palermo, Palermo, Italy.
Tomasz SledzinskiDepartment of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Gdańsk, Gdańsk, Poland.
Gdańsk Medical University · PLIstituto Euro Mediterraneo di Scienza e Tecnologia · ITUniversità degli Studi eCampus · ITUniversity of Palermo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increased physical activity is an optimal way to maintain a good health. During exercise, triacylglycerols, an energy reservoir in adipose tissue, are hydrolyzed to free fatty acids (FAs) which are then released to the circulation, providing a fuel for working muscles. Thus, regular physical activity leads to a reduction of adipose tissue mass and improves metabolism. However, the reduction of lipid reservoir is also associated with many other interesting changes in adipose tissue FA metabolism. For example, a prolonged exercise contributes to a decrease in lipoprotein lipase activity and resultant reduction of FA uptake. This results in the improvement of mitochondrial function and upregulation of enzymes involved in the metabolism of polyunsaturated fatty acids. The exercise-induced changes in adipocyte metabolism are associated with modifications of FA composition. The modifications are adipose tissue depot-specific and follow different patterns in visceral and subcutaneous adipose tissue. Moreover, exercise affects adipokine release from adipose tissue, and thus, may mitigate inflammation and improve insulin sensitivity. Another consequence of exercise is the recently described phenomenon of adipose tissue "beiging," i.e., a switch from energy-storing white adipocyte phenotype to thermogenic FA oxidizing beige adipocytes. This process is regulated by myokines released during the exercise. In this review, we summarize published evidence for the exercise-related changes in FA metabolism and adipokine release in adipose tissue, and their potential contribution to beneficial cardiovascular and metabolic effects of physical activity.

Indexed as

adipokineadipose tissueadipose tissue beigingexercisefatty acidmyokine

Identifiers

PMID30745881
PMCPMC6360148
OpenAlexW2913707382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.