Evidence map›Paper›PMID 30745817›Full record

ArticleInternational journal of medical sciences2019

Gene Expression Profiling in Ischemic Postconditioning to Alleviate Mouse Liver Ischemia/Reperfusion Injury.

Pengpeng Zhang, Yingzi Ming, Ke Cheng, Ying Niu, Qifa Ye

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Contradictory Role of Gadd45β in Liver Diseases.Journal of cellular and molecular medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pengpeng ZhangDepartment of Transplant Surgery, The Third Xiangya Hospital of Central South University, Changsha 410013, China.
Yingzi MingDepartment of Transplant Surgery, The Third Xiangya Hospital of Central South University, Changsha 410013, China.
Ke ChengDepartment of Transplant Surgery, The Third Xiangya Hospital of Central South University, Changsha 410013, China.
Ying NiuDepartment of Transplant Surgery, The Third Xiangya Hospital of Central South University, Changsha 410013, China.
Qifa YeDepartment of Transplant Surgery, The Third Xiangya Hospital of Central South University, Changsha 410013, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic postconditioning (IPO) attenuates hepatic ischemia/reperfusion (I/R) injury. However, little is known about the underlying biological pathophysiology, which could be, at least in part, informed by exploring the transcriptomic changes using next-generation RNA sequencing (RNA-Seq). In this study, 18 mice (C57BL/6) were involved and randomly assigned to three groups: normal (n=6), I/R (n=6, subjected to 70% hepatic I/R), and IR+IPO (n=6, applying IPO to mice with I/R injury). We randomly selected 3 mice per group and extracted their liver tissues for next-generation RNA-Seq. We performed a bioinformatics analysis for two comparisons: normal vs. I/R and I/R vs. IR+IPO. From the analysis, 2416 differentially expressed genes (DEGs) were identified (

Indexed as

Gene Expression ProfilingIschemic PostconditioningAnimalsLiver DiseasesMaleMice, Inbred C57BLRandom AllocationReperfusion InjurySequence Analysis, RNADEGshepatic ischemia-reperfusion injuryischemic postconditioningMAPK pathwaynext-generation RNA-Seq

Identifiers

PMID30745817
PMCPMC6367534

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.