Evidence map›Paper›PMID 30745564›Full record

ArticleTranslational psychiatry2019

PET imaging of the mouse brain reveals a dynamic regulation of SERT density in a chronic stress model.

Sonali N Reisinger, Thomas Wanek, Oliver Langer, Daniela D Pollak

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Quantifying microglial morphology: an insight into function.Clinical and experimental immunology · 2024
    Review
  4. PET imaging of animal models with depressive-like phenotypes.European journal of nuclear medicine and molecular imaging · 2023
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sonali N ReisingerDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Schwarzspanierstraße 17, 1090, Vienna, Austria.
Thomas WanekBiomedical Systems, AIT Austrian Institute of Technology GmbH, 2444, Seibersdorf, Austria.
Oliver LangerBiomedical Systems, AIT Austrian Institute of Technology GmbH, 2444, Seibersdorf, Austria.
Daniela D PollakDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Schwarzspanierstraße 17, 1090, Vienna, Austria. daniela.pollak@meduniwien.ac.at.
Austrian Institute of Technology · ATMedical University of Vienna · AT

Funding

Austrian Science Fund FWF P 28683
6 · The paper itself

Abstract

The serotonin transporter (SERT, Slc6a4) plays an important role in the regulation of serotonergic neurotransmission and its aberrant expression has been linked to several psychiatric conditions. While SERT density has been proven to be amenable to in vivo quantitative evaluation by positron emission tomography (PET) in humans, this approach is in its infancy for rodents. Here we set out to evaluate the feasibility of using small-animal PET employing [

Indexed as

Aniline CompoundsAnimalsBrainCorticosteroneDepressionFemaleMaleMice, Inbred C57BLMice, KnockoutPositron-Emission TomographySerotonin Plasma Membrane Transport ProteinsStress, PsychologicalSulfides3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrileAniline CompoundsCorticosteroneSerotonin Plasma Membrane Transport ProteinsSlc6a4 protein, mouseSulfides

Identifiers

PMID30745564
PMCPMC6370816
OpenAlexW2914068714

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.