ArticleTranslational psychiatry2019
Sex-specific deficits in neurite density and white matter integrity are associated with targeted disruption of exon 2 of the Disc1 gene in the rat.
Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Microstructural Alterations of the Corpus Callosum in Patients with First-Episode Schizophrenia Revealed by NODDI: Dissociation Between Neurite Density and Orientation Dispersion in the Splenium.Bioengineering (Basel, Switzerland) · 2026Article
- Cellular deconvolution of the brain with topological magnetic resonance image analysis.bioRxiv : the preprint server for biology · 2025Article
- Polygenic scores for autism are associated with reduced neurite density in adults and children from the general population.Molecular psychiatry · 2025Article
- Polygenic scores for autism are associated with neurite density in adults and children from the general population.medRxiv : the preprint server for health sciences · 2024Article
- Quantitative diffusion imaging and genotype-by-sex interactions in a rat model of Alexander disease.Magnetic resonance in medicine · 2024Article
- Diffusion radiomics for subtyping and clustering in autism spectrum disorder: A preclinical study.Magnetic resonance imaging · 2023Article
- Increased expression of SLC25A1/CIC causes an autistic-like phenotype with altered neuron morphology.Brain : a journal of neurology · 2022Article
- Clinical translational neuroimaging of the antioxidant effect of N-acetylcysteine on neural microstructure.Magnetic resonance in medicine · 2022Article
- SLC13A5/sodium-citrate co-transporter overexpression causes disrupted white matter integrity and an autistic-like phenotype.Brain communications · 2022Article
- Article
- Neurite Orientation Dispersion and Density Imaging (NODDI) and Duration of Untreated Psychosis in Antipsychotic Medication-Naïve First Episode Psychosis Patients.Neuroimage. Reports · 2021Article
- Assessment of Mosaicism and Detection of Cryptic Alleles in CRISPR/Cas9-Engineered Neurofibromatosis Type 1 andFrontiers in genetics · 2021Article
- Rat models of human diseases and related phenotypes: a systematic inventory of the causative genes.Journal of biomedical science · 2020Review
- Convergent brain microstructure across multiple genetic models of schizophrenia and autism spectrum disorder: A feasibility study.Magnetic resonance imaging · 2020Article
- Article
- Expression of Behavioral Phenotypes in Genetic and Environmental Mouse Models of Schizophrenia.Frontiers in behavioral neuroscience · 2020Article
- Exercise ameliorates deficits in neural microstructure in a Disc1 model of psychiatric illness.Magnetic resonance imaging · 2019Article
- Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Diffusion tensor imaging (DTI) has provided remarkable insight into our understanding of white matter microstructure and brain connectivity across a broad spectrum of psychiatric disease. While DTI and other diffusion weighted magnetic resonance imaging (MRI) methods have clarified the axonal contribution to the disconnectivity seen in numerous psychiatric diseases, absent from these studies are quantitative indices of neurite density and orientation that are especially important features in regions of high synaptic density that would capture the synaptic contribution to the psychiatric disease state. Here we report the application of neurite orientation dispersion and density imaging (NODDI), an emerging microstructure imaging technique, to a novel Disc1 svΔ2 rat model of psychiatric illness and demonstrate the complementary and more specific indices of tissue microstructure found in NODDI than those reported by DTI. Our results demonstrate global and sex-specific changes in white matter microstructural integrity and deficits in neurite density as a consequence of the Disc1 svΔ2 genetic variation and highlight the application of NODDI and quantitative measures of neurite density and neurite dispersion in psychiatric disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.