ArticleThe Journal of reproduction and development2019
Improvement of fertility in repeat breeder dairy cattle by embryo transfer following artificial insemination: possibility of interferon tau replenishment effect.
Article in The Journal of reproduction and development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Calving outcomes after ipsilateral versus contralateral supplementary embryo transfer in repeat-breeder Holstein cows.Animal reproduction · 2026Article
- The High Frequency of a G-Allele Variant of theAnimals : an open access journal from MDPI · 2025Article
- Effects of Two Hormonal Protocols for FTAI on the Fertility of Repeat Cows.International journal of molecular sciences · 2025Article
- Assisted Reproduction Technologies (ART): Impact of Mitochondrial (Dys)function and Antioxidant Therapy.Animals : an open access journal from MDPI · 2025Review
- Evaluation of the effect of sustained-release progesterone injection on the expression of interferon-related genes in repeat-breeder dairy cows.Veterinary medicine and science · 2024Article
- Inflammatory uterine microenvironment in long-term infertility repeat breeder cows compared with normal fertile cows.Veterinary and animal science · 2024Article
- Seasonal distribution of repeat breeder cows and evaluation of modified protocols for post AI treatment during summer.Tropical animal health and production · 2023Article
- Recent progress of interferon-tau research and potential direction beyond pregnancy recognition.The Journal of reproduction and development · 2022Review
- Ovarian luteal category at the time of exogenous progesterone treatment alters pre-ovulatory follicle size and pregnancy outcome but not initial GnRH treatment in repeat-breeder crossbred dairy heifers submitted to the 7-day fixed-time AI protocol.Veterinary and animal science · 2022Article
- Frequency of an X-Linked Maternal Variant of the BovineAnimals : an open access journal from MDPI · 2022Article
- Embryo Transfer as an Option to Improve Fertility in Repeat Breeder Dairy Cows.Journal of veterinary research · 2021Article
- Metabolomic profiles of plasma and uterine luminal fluids from healthy and repeat breeder Holstein cows.BMC veterinary research · 2021Article
- Benefits and Risks of Preventing Twin Pregnancies.Animals : an open access journal from MDPI · 2021Review
- Profiles of progesterone and bovine interferon-τ in repeat breeding and non-repeat breeding Aceh cows.Veterinary world · 2021Article
- Adverse reproductive effects of S100A9 on bovine sperm and early embryonic development in vitro.PloS one · 2020Article
- The transfer of parthenogenetic embryos following artificial insemination in cows can enhance pregnancy recognition via the secretion of interferon tau.The Journal of reproduction and development · 2019Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Repeat breeder cattle do not become pregnant until after three or more breeding attempts; this represents a critical reproductive disorder. Embryo transfer (ET) following artificial insemination (AI) in repeat breeder cattle reportedly improves pregnancy rate, leading to speculation that interferon tau (IFNT) is associated with this phenomenon. However, the reason why the conception rate improves remains unknown. We investigated the effect of ET following AI on repeat breeder cattle in field tests, and determined whether adding an embryo affects the maternal immune cells detected by interferon-stimulated genes (ISGs), marker genes of IFN response. In total, 1122 repeat breeder cattle were implanted with in vitro fertilization (IVF) embryos after previous AI. ET following AI resulted in pregnancy rates of 46.9% in repeat breeder dairy cattle. In basic in vivo tests, to investigate the effect of adding embryos, ISGs mRNA expression levels were significantly higher in the AI + ET group than in the AI + sham group (transfer of only embryonic cryopreservation solution). Then, we examined the effect of cultured conditioned media (CM) of IVF embryos on splenic immune cells and Madin-Darby bovine kidney (MDBK) cells with stably introduced ISG15 promoter-reporter constructs. These cells exhibited a specific increase in ISG15 mRNA expression and promoter activity when treated with the CM of IVF embryos, suggesting that IVF embryos have the potential to produce and release IFNT. In conclusion, ET following AI is beneficial for improving conception in repeat breeder cattle. Added embryos may produce and secrete IFNT, resulting in the increased expression of ISGs.
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