Evidence map›Paper›PMID 30745457›Full record

ArticleBioscience reports2019

Ablation of both Cx40 and Panx1 results in similar cardiovascular phenotypes exhibited in Cx40 knockout mice.

Nicole M Novielli-Kuntz, Meghan Jelen, Kevin Barr, Leon J DeLalio, Qingping Feng, Brant E Isakson, Robert Gros, Dale W Laird

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Pannexins in the vasculature.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  3. Review
  4. Renin Cells, the Kidney, and Hypertension.Circulation research · 2021
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Nicole M Novielli-KuntzDepartment of Anatomy and Cell Biology, University of Western Ontario, London, Canada.
Meghan JelenDepartment of Anatomy and Cell Biology, University of Western Ontario, London, Canada.
Kevin BarrDepartment of Anatomy and Cell Biology, University of Western Ontario, London, Canada.
Leon J DeLalioRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, U.S.A.
Qingping FengDepartment of Physiology and Pharmacology London, ON, Canada.
Brant E IsaksonRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, U.S.A.
Robert GrosDepartment of Physiology and Pharmacology London, ON, Canada.
Dale W LairdDepartment of Anatomy and Cell Biology, University of Western Ontario, London, Canada Dale.laird@schulich.uwo.ca.ORCID 0000-0002-4568-3285
Western University · CAUniversity of Virginia · US

Funding

Role of Pannexins in Vascular Smooth Muscle CellsP01HL120840 · NHLBI · UNIVERSITY OF VIRGINIA · PI BAYLISS, DOUGLAS A., RAVICHANDRAN, KODI S · 2014 to 2023
$24.0M
CIHR 130530NHLBI NIH HHS P01 HL120840
6 · The paper itself

Abstract

Connexins (Cxs) and pannexins (Panxs) are highly regulated large-pore channel-forming proteins that participate in cellular communication via small molecular exchange with the extracellular microenvironment, or in the case of connexins, directly between cells. Given the putative functional overlap between single membrane-spanning connexin hemichannels and Panx channels, and cardiovascular system prevalence, we generated the first Cx40

Indexed as

Gene DeletionAnimalsCardiomegalyConnexinsFibrosisGap Junction alpha-5 ProteinHypertensionMaleMice, Inbred C57BLMice, KnockoutMyocardiumNerve Tissue ProteinsConnexinsGap Junction alpha-5 ProteinNerve Tissue ProteinsPanx1 protein, mouseconnexingap junctionsPannexin 1

Identifiers

PMID30745457
PMCPMC6393227
OpenAlexW2913938468

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.