Evidence map›Paper›PMID 30745437›Full record

ArticleBiology open2019

Edar is a downstream target of beta-catenin and drives collagen accumulation in the mouse prostate.

Kyle A Wegner, Vatsal Mehta, Jeanette A Johansson, Brett R Mueller, Kimberly P Keil, Lisa L Abler, Paul C Marker, M Mark Taketo, Denis J Headon, Chad M Vezina

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Kyle A WegnerMolecular and Environmental Toxicology Center University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID http://orcid.org/0000-0003-1309-0060
Vatsal MehtaDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID http://orcid.org/0000-0002-8032-5571
Jeanette A JohanssonThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh EH25 9RG, United Kingdom.ORCID http://orcid.org/0000-0002-2581-9368
Brett R MuellerDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Kimberly P KeilDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Lisa L AblerDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Paul C MarkerSchool of Pharmacy, University of Wisconsin-Madison, Madison, WI 53706, USA.
M Mark TaketoDivision of Experimental Therapeutics, Graduate School of Medicine, Kyoto University Yoshida-Konoé-cho, Sakyo, Kyoto 606-8501, Japan.
Denis J HeadonThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh EH25 9RG, United Kingdom.
Chad M VezinaDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA chad.vezina@wisc.edu.ORCID http://orcid.org/0000-0001-7058-5399
University of Wisconsin–Madison · USRoslin Institute · GBKyoto University · JP

Funding

Role of Beta-Catenin in Urinary DysfunctionU54DK104310 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI MACOSKA, JILL A., MARKER, PAUL C · 2014 to 2023
$12.8M
Molecular & Environmental Toxicology Pre-& Postdoctoral Training ProgramT32ES007015 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI CHRISTOPHER A BRADFIELD · 1985 to 2026
$11.5M
Steroid hormones and SFRP1 in the age-related incidence of BPH and BOOR01DK091193 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI MARKER, PAUL C · 2011 to 2015
$1.6M
TCDD Reprograms Prostate Stroma and Causes Fibrosis to Induce Urinary DysfunctionF31ES028594 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI WEGNER, KYLE ALLEN · 2018 to 2019
$54k
NIDDK NIH HHS R01 DK091193NIDDK NIH HHS U54 DK104310NIEHS NIH HHS F31 ES028594NIEHS NIH HHS T32 ES007015
6 · The paper itself

Abstract

Beta-catenin (CTNNB1) directs ectodermal appendage spacing by activating ectodysplasin A receptor (EDAR) transcription, but whether CTNNB1 acts by a similar mechanism in the prostate, an endoderm-derived tissue, is unclear. Here we examined the expression, function, and CTNNB1 dependence of the EDAR pathway during prostate development.

Indexed as

CollagenCTNNB1EDARProstateUrogenital sinusWNT10B

Identifiers

PMID30745437
PMCPMC6451354
OpenAlexW2911480502

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.