Evidence map›Paper›PMID 30745415›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2019

Targeting Dopamine D

Mark H Lewis, Christopher T Primiani, Amber M Muehlmann

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Drug development for Autism Spectrum Disorder (ASD): Progress, challenges, and future directions.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2021
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mark H LewisDepartment of Psychiatry, University of Florida, Gainesville, Florida.
Christopher T PrimianiDepartment of Psychiatry, University of Florida, Gainesville, Florida.
Amber M MuehlmannDepartment of Psychiatry, University of Florida, Gainesville, Florida muehlman@ufl.edu.ORCID 0000-0002-0961-0839
University of Florida · US

Funding

UF CLINICAL AND TRANSLATIONAL SCIENCE AWARDUL1RR029890 · NCRR · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2009 to 2011
$14.4M
Development of Persistent Repetitive Behavior in AnimalsR01MH080055 · NIMH · UNIVERSITY OF FLORIDA · PI LEWIS, MARK H · 2009 to 2015
$2.1M
Profiling direct/indirect basal ganglia cells in restricted repetitive behaviorF32MH092114 · NIMH · UNIVERSITY OF FLORIDA · PI MUEHLMANN, AMBER M · 2010 to 2012
$94k
NCRR NIH HHS UL1 RR029890NIMH NIH HHS F32 MH092114NIMH NIH HHS R01 MH080055
6 · The paper itself

Abstract

Repetitive behaviors are seemingly purposeless patterns of behavior that vary little in form and are characteristic of many neurodevelopmental, psychiatric, and neurologic disorders. Our work has identified an association between hypofunctioning of the indirect basal ganglia pathway and the expression of repetitive behavior in the deer mouse model. In this study, we targeted indirect pathway cells of the striatum with single drugs and drug combinations that bind to dopamine D

Indexed as

AnimalsBehavior, AnimalDose-Response Relationship, DrugDrug InteractionsMaleMolecular Targeted TherapyPeromyscusReceptor, Adenosine A2AReceptor, Metabotropic Glutamate 5Receptors, Dopamine D2Time FactorsReceptor, Adenosine A2AReceptor, Metabotropic Glutamate 5Receptors, Dopamine D2

Identifiers

PMID30745415
PMCPMC6423618
OpenAlexW2911387261

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.