Evidence map›Paper›PMID 30745375›Full record

ArticleJournal of bacteriology2019

Inorganic Polyphosphate Accumulation in Escherichia coli Is Regulated by DksA but Not by (p)ppGpp.

Michael J Gray

Open access · bronzeAbstract read
In one paragraph

Article in Journal of bacteriology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. The roles and synthesis of inorganic polyphosphate inbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Virulence Regulation inMicroorganisms · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. The Protein Scaffolding Functions of Polyphosphate.Journal of molecular biology · 2024
    Review
  17. Article
  18. Article
  19. The role of metals in hypothiocyanite resistance inbioRxiv : the preprint server for biology · 2024
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Michael J GrayDepartment of Microbiology, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA mjgray@uab.edu.ORCID 0000-0002-7112-4188
University of Alabama at Birmingham · US

Funding

Molecular Mechanisms of Bacterial Stress Response Relevant to Host-Microbe InteractionsR35GM124590 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael Jeffrey Gray · 2017 to 2026
$3.5M
NIGMS NIH HHS R35 GM124590
6 · The paper itself

Abstract

Production of inorganic polyphosphate (polyP) by bacteria is triggered by a variety of different stress conditions. polyP is required for stress survival and virulence in diverse pathogenic microbes. Previous studies have hypothesized a model for regulation of polyP synthesis in which production of the stringent-response second messenger (p)ppGpp directly stimulates polyP accumulation. In this work, I have now shown that this model is incorrect, and (p)ppGpp is not required for polyP synthesis in

Indexed as

Gene Expression Regulation, BacterialEscherichia coliEscherichia coli ProteinsGene DeletionGuanosine PentaphosphateGuanosine TetraphosphatePhosphatesPolyphosphatesTranscription FactorsdksA protein, E coliEscherichia coli ProteinsGreA protein, E coliGuanosine PentaphosphateGuanosine TetraphosphatePhosphatesPolyphosphatesTranscription FactorsDksAinorganic polyphosphate(p)ppGppstringent response

Identifiers

PMID30745375
PMCPMC6456864
OpenAlexW2912413857

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.