Evidence map›Paper›PMID 30745360›Full record

ArticleThe Journal of biological chemistry2019

Melanocortin type 4 receptor-mediated inhibition of A-type K

Yuan Zhang, Dongsheng Jiang, Hua Li, Yufang Sun, Xinghong Jiang, Shan Gong, Zhiyuan Qian, Jin Tao

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 36 citations in OpenAlex.

  1. Observational
  2. The Skin-Brain Axis: From UV and Pigmentation to Behaviour Modulation.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yuan ZhangFrom the Department of Geriatrics, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Dongsheng Jiangthe Department of Physiology and Neurobiology and Centre for Ion Channelopathy, Medical College of Soochow University, Suzhou 215123, China.
Hua Lithe National Shanghai Center for New Drug Safety Evaluation and Research, Shanghai 201203, China.
Yufang Sunthe Department of Physiology and Neurobiology and Centre for Ion Channelopathy, Medical College of Soochow University, Suzhou 215123, China.
Xinghong Jiangthe Department of Physiology and Neurobiology and Centre for Ion Channelopathy, Medical College of Soochow University, Suzhou 215123, China.
Shan Gongthe Department of Physiology and Neurobiology and Centre for Ion Channelopathy, Medical College of Soochow University, Suzhou 215123, China.
Zhiyuan QianFrom the Department of Geriatrics, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China, zhiyuanqian@suda.edu.cn.
Jin Taothe Department of Physiology and Neurobiology and Centre for Ion Channelopathy, Medical College of Soochow University, Suzhou 215123, China, taoj@suda.edu.cn.
Soochow University · CNNational Center for Drug Screening · CNSecond Affiliated Hospital of Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

α-Melanocyte-stimulating hormone (α-MSH) has been shown to be involved in nociception, but the underlying molecular mechanisms remain largely unknown. In this study, we report that α-MSH suppresses the transient outward A-type K

Indexed as

Action Potentialsalpha-MSHAnimalsGTP-Binding ProteinsPainPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsPotassium ChannelsRatsRats, Sprague-DawleyReceptor, Melanocortin, Type 4Sensory Receptor CellsSignal TransductionTrigeminal GanglionWortmanninalpha-MSHGTP-Binding Proteinsmelanocortin receptor type 4, ratPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsPotassium ChannelsReceptor, Melanocortin, Type 4Wortmanninaction potentialalpha-melanocyte-stimulating hormoneA-type K+ currentcell signalingelectrophysiologyG-protein-coupled receptor (GPCR)ion channelmelanocortin type 4 receptor (MC4R)neuronal excitabilitynociceptionpainpain perceptionpatch clamppotassium channelsignal transductiontrigeminal ganglion neurons

Identifiers

PMID30745360
PMCPMC6462507
OpenAlexW2913118644

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.