Evidence map›Paper›PMID 30745276›Full record

ArticleThe Lancet. Infectious diseases2019

Hand-to-genital and genital-to-genital transmission of human papillomaviruses between male and female sexual partners (HITCH): a prospective cohort study.

Talía Malagón, Karolina Louvanto, Michel Wissing, Ann N Burchell, Pierre-Paul Tellier, Mariam El-Zein, François Coutlée, Eduardo L Franco

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PubMed Full text at PMC Publisher
In one paragraph

Article in The Lancet. Infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Talía MalagónDivision of Cancer Epidemiology, Department of Oncology, McGill University, Montreal, QC, Canada. Electronic address: talia.malagon@mcgill.ca.
Karolina LouvantoDepartment of Obstetrics and Gynaecology, Turku University Hospital, University of Turku, Turku, Finland.
Michel WissingDivision of Cancer Epidemiology, Department of Oncology, McGill University, Montreal, QC, Canada.
Ann N BurchellDepartment of Family and Community Medicine and Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada; Department of Family and Community Medicine and Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Pierre-Paul TellierDepartment of Family Medicine, McGill University, Montreal, QC, Canada.
Mariam El-ZeinDivision of Cancer Epidemiology, Department of Oncology, McGill University, Montreal, QC, Canada.
François CoutléeDépartement de Microbiologie et Infectiologie, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada; Département de Microbiologie et Immunologie, Université de Montréal, Montreal, QC, Canada.
Eduardo L FrancoDivision of Cancer Epidemiology, Department of Oncology, McGill University, Montreal, QC, Canada; Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada.
McGill University · CACentre Hospitalier de l’Université de Montréal · CAPublic Health Ontario · CATurku University Hospital · FI

Funding

HITCH: A Study of HPV Transmission in Young CouplesR01AI073889 · NIAID · MCGILL UNIVERSITY · PI FRANCO, EDUARDO L. · 2010 to 2013
$419k
NIAID NIH HHS R01 AI073889
6 · The paper itself

Abstract

backgroundHand-to-genital contact is hypothesised to be a transmission mode of human papillomavirus (HPV) of the Alphapapillomavirus genus. We compared the relative importance of hand-to-genital and genital-to-genital HPV transmission between sexual partners.

methodsIn this prospective cohort study, we recruited and followed up female university students aged 18-24 years and their male sexual partners in Montreal, QC, Canada (2005-11). Participants were eligible if they had initiated sexual activity within the past 6 months. Women were examined at clinic visits at baseline and every 4-6 months for up to 24 months. Men had a baseline visit and a single follow-up visit approximately 4 months later. Partners provided hand and genital swab samples, which we tested for DNA of 36 HPV types using PCR. We assessed predictors of incident type-specific HPV detections using Cox proportional hazards models.

findingsParticipants were recruited between June 5, 2006, and April 4, 2013. 264 women and 291 men had valid hand samples. The hazard ratio (HR) of incident detection of HPV in genital samples from women was 5·0 (95% CI 1·5-16·4) when her partner was positive for the same HPV type on his hand versus negative, but adjustment for his genital HPV status reduced the HR to 0·5 (0·1-1·8). Similarly, the HR of incident detection of HPV on men's genitals was 17·4 (95% CI 7·9-38·5) when his partner was positive for the same HPV type on her hand versus negative, but adjustment for her genital HPV status reduced the HR to 2·3 (0·9-6·2). Conversely, the HR of type-specific incident detection of HPV in genital samples associated with partner genital HPV positivity was 19·3 (95% CI 11·8-31·8) for women and 28·4 (15·4-52·1) for men after adjustment for their hand HPV status.

interpretationClinicians can reassure their patients that HPV transmission is unlikely to occur through hand-to-genital contact. The majority of genital HPV infections are likely to be caused by genital-to-genital sexual transmission.

fundingCanadian Institutes for Health Research, National Institutes of Health, Fonds de la Recherche en Santé du Québec, and Merck & Co.

Indexed as

Disease Transmission, InfectiousSexual PartnersAdolescentDNA, ViralFemaleGenitaliaGenotyping TechniquesHandHumansMalePapillomaviridaePapillomavirus InfectionsPolymerase Chain ReactionProspective StudiesQuebecSexually Transmitted Diseases, ViralDNA, Viral

Identifiers

PMID30745276
PMCPMC6404546
OpenAlexW2912330999

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.