ArticleMolecular cell2019
Deciphering the Molecular Mechanism Underpinning Phage Arbitrium Communication Systems.
Article in Molecular cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 55 citations in OpenAlex.
- Revisiting the life cycle of temperate phages.Nature reviews. Microbiology · 2026Review
- The molecular basis of ADP-ribose pyrophosphorylation by a phage PRPS-like enzyme in NAD+ reconstitution.Nucleic acids research · 2026Article
- Competing Inter-Domain Quorum-Sensing Systems Control Prophage Lysis-Lysogeny Decisions.bioRxiv : the preprint server for biology · 2026Article
- Decoding phage communication: molecular networks, evolutionary dynamics, and therapeutic applications.NPJ biofilms and microbiomes · 2026Review
- Article
- Structural phylogenetics unravels the evolutionary diversification of communication systems in gram-positive bacteria and their viruses.Nature structural & molecular biology · 2025Article
- Review of the Arbitrium (ARM) System: Molecular Mechanisms, Ecological Impacts, and Applications in Phage-Host Communication.Microorganisms · 2025Review
- Lysogenic control of Bacillus subtilis morphology and fitness by Spbetavirus phi3T.Communications biology · 2025Article
- The Role of Quorum Sensing in Phage Lifecycle Decision: A Switch Between Lytic and Lysogenic Pathways.Viruses · 2025Review
- Extracellular proteolysis of tandemly duplicated pheromone propeptides affords additional complexity to bacterial quorum sensing.PLoS biology · 2024Article
- Antagonistic interactions between phage and host factors control arbitrium lysis-lysogeny decision.Nature microbiology · 2024Article
- Structural and functional characterization of MrpR, the master repressor of the Bacillus subtilis prophage SPβ.Nucleic acids research · 2023Article
- Article
- A secreted effector with a dual role as a toxin and as a transcriptional factor.Nature communications · 2022Article
- Non-canonical Staphylococcus aureus pathogenicity island repression.Nucleic acids research · 2022Article
- Insights into the mechanism of action of the arbitrium communication system in SPbeta phages.Nature communications · 2022Article
- Article
- The arbitrium system controls prophage induction.Current biology : CB · 2021Article
- Regulation of prophage induction and lysogenization by phage communication systems.Current biology : CB · 2021Article
- Towards the Idea of Molecular Brains.International journal of molecular sciences · 2021Review
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Bacillus phages use a communication system, termed "arbitrium," to coordinate lysis-lysogeny decisions. Arbitrium communication is mediated by the production and secretion of a hexapeptide (AimP) during lytic cycle. Once internalized, AimP reduces the expression of the negative regulator of lysogeny, AimX, by binding to the transcription factor, AimR, promoting lysogeny. We have elucidated the crystal structures of AimR from the Bacillus subtilis SPbeta phage in its apo form, bound to its DNA operator and in complex with AimP. AimR presents intrinsic plasticity, sharing structural features with the RRNPP quorum-sensing family. Remarkably, AimR binds to an unusual operator with a long spacer that interacts nonspecifically with the receptor TPR domain, while the HTH domain canonically recognizes two inverted repeats. AimP stabilizes a compact conformation of AimR that approximates the DNA-recognition helices, preventing AimR binding to the aimX promoter region. Our results establish the molecular basis of the arbitrium communication system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.