Evidence map›Paper›PMID 30745004›Full record

ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2019

Disruptions in White Matter Maturation and Mediation of Cognitive Development in Youths on the Psychosis Spectrum.

Catherine E Hegarty, Dietsje D Jolles, Eva Mennigen, Maria Jalbrzikowski, Carrie E Bearden, Katherine H Karlsgodt

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Cognitive Dysfunction as a Risk Factor for Psychosis.Current topics in behavioral neurosciences · 2023
    Article
  4. Article
  5. Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Catherine E HegartyDepartment of Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California.
Dietsje D JollesDepartment of Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California.
Eva MennigenDepartment of Psychiatry and Behavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California.
Maria JalbrzikowskiDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
Carrie E BeardenDepartment of Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California; Department of Psychiatry and Behavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California; Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, California.
Katherine H KarlsgodtDepartment of Psychology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California. Electronic address: kkarlsgo@ucla.edu.
University of California, Los Angeles · USUniversity of Pittsburgh · US

Funding

Multimodal Imaging of Executive and Reward Networks Across the Psychosis SpectrumR01MH101506 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KARLSGODT, KATHERINE HELEN · 2013 to 2017
$2.5M
Genetic Risk for Developmental Expression of Neuropsychiatric Intermediate TraitsR01MH107250 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, OPHOFF, ROEL A · 2015 to 2017
$1.7M
Neurodevelopmental variation of intrinsic functional connectivity and its relationship to psychosis risk and gene expression - SupplementK01MH112774 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JALBRZIKOWSKI, MARIA · 2017 to 2022
$884k
NIMH NIH HHS K01 MH112774NIMH NIH HHS R01 MH101506NIMH NIH HHS R01 MH107250
6 · The paper itself

Abstract

backgroundPsychosis onset typically occurs in adolescence, and subclinical psychotic experiences peak in adolescence. Adolescence is also a time of critical neural and cognitive maturation. Using cross-sectional data from the Philadelphia Neurodevelopmental Cohort, we examined whether regional white matter (WM) development is disrupted in youths with psychosis spectrum (PS) features and whether WM maturation mediates the relationship between age and cognition in typically developing (TD) youths and youths with PS features.

methodsWe examined WM microstructure, as assessed via diffusion tensor imaging, in 670 individuals (age 10-22 years; 499 TD group, 171 PS group) by using tract-based spatial statistics. Multiple regressions were used to evaluate age × group interactions on regional WM indices. Mediation analyses were conducted on four cognitive domains-executive control, complex cognition, episodic memory, and social cognition-using a bootstrapping approach.

resultsThere were age × group interactions on fractional anisotropy (FA) in the superior longitudinal fasciculus (SLF) and retrolenticular internal capsule. Follow-up analyses revealed these effects were significant in both hemispheres. Bilateral SLF FA mediated the relationship between age and complex cognition in the TD group, but not the PS group. Regional FA did not mediate the age-associated increase in any of the other cognitive domains.

conclusionsOur results showed aberrant age-related effects in SLF and retrolenticular internal capsule FA in youths with PS features. SLF development supports emergence of specific higher-order cognitive functions in TD youths, but not in youths with PS features. Future mechanistic explanations for these relationships could facilitate development of earlier and refined targets for therapeutic interventions.

Indexed as

AdolescentAdultBrainChildCognitionCross-Sectional StudiesDiffusion Tensor ImagingFemaleHumansMalePsychotic DisordersWhite MatterYoung AdultCognitionDevelopmentDTIMediationPsychosis spectrumPsychotic-like experiencesSubclinical psychosisSuperior longitudinal fasciculus

Identifiers

PMID30745004
PMCPMC6941904
OpenAlexW2952185451

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.