ArticleNeuron2019
Hierarchical Heterogeneity across Human Cortex Shapes Large-Scale Neural Dynamics.
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 204 papers, 2 of them syntheses that pooled it.
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Who cites it
204 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex.Nature communications · 2022Pooled it
- Neuroanatomical and psychological considerations in temporal lobe epilepsy.Frontiers in neuroanatomy · 2022Pooled it
- Trial
- Memantine Effects on Electroencephalographic Measures of Putative Excitatory/Inhibitory Balance in Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Trial
- Intrinsic timescale develops hierarchically from sensorimotor to association cortex in youth and stabilizes in adulthood.PLoS biology · 2026Article
- State-dependent signal flow hierarchy in the human cerebral cortex.Nature neuroscience · 2026Article
- Human cortex organizes dynamic co-fluctuations along the sensorimotor-association axis.Nature communications · 2026Article
- The prefrontal cortex across scales: laminar architecture, white-matter constraints, and distributed control in cognition.Brain structure & function · 2026Review
- Spatially structured heterogeneity shapes large-scale cortical dynamics in a model of the human cortex.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The human language processing system straightens natural speech.bioRxiv : the preprint server for biology · 2026Article
- Schooling Trajectories and the Development of Brain Dynamics: A Comparative Study of Montessori and Traditional Education.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Neuromorphic hierarchical modular reservoirs.Nature communications · 2026Article
- Opportunities and pitfalls of data contextualization in neuroimaging.Nature reviews. Neuroscience · 2026Review
- Categorization is 'baked' into the brain.Nature reviews. Neuroscience · 2026Review
- Tract-explainable and underexplained synchrony play complementary roles in the functional organization of the brain.bioRxiv : the preprint server for biology · 2026Article
- Global topology of brain-wide co-fluctuations links task states, personality, and behavioral symptom dimensions.bioRxiv : the preprint server for biology · 2026Article
- Association-sensory spatiotemporal hierarchy and functional gradient-regularised recurrent neural network with implications for schizophrenia.NPJ systems biology and applications · 2026Article
- Competitive interactions shape mammalian brain network dynamics and computation.Nature neuroscience · 2026Article
- Emotion regulation success involves systematic gradient-based reconfigurations of large-scale activation patterns in the human brain.PLoS biology · 2026Article
- Personalized whole-brain Ising models with heterogeneous nodes capture differences among brain regions.bioRxiv : the preprint server for biology · 2026Article
144 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The large-scale organization of dynamical neural activity across cortex emerges through long-range interactions among local circuits. We hypothesized that large-scale dynamics are also shaped by heterogeneity of intrinsic local properties across cortical areas. One key axis along which microcircuit properties are specialized relates to hierarchical levels of cortical organization. We developed a large-scale dynamical circuit model of human cortex that incorporates heterogeneity of local synaptic strengths, following a hierarchical axis inferred from magnetic resonance imaging (MRI)-derived T1- to T2-weighted (T1w/T2w) mapping and fit the model using multimodal neuroimaging data. We found that incorporating hierarchical heterogeneity substantially improves the model fit to functional MRI (fMRI)-measured resting-state functional connectivity and captures sensory-association organization of multiple fMRI features. The model predicts hierarchically organized higher-frequency spectral power, which we tested with resting-state magnetoencephalography. These findings suggest circuit-level mechanisms linking spatiotemporal levels of analysis and highlight the importance of local properties and their hierarchical specialization on the large-scale organization of human cortical dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.