ArticlePsychological medicine2019
Error-related brain activity as a transdiagnostic endophenotype for obsessive-compulsive disorder, anxiety and substance use disorder.
Article in Psychological medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
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Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 126 citations in OpenAlex.
- Problematic Gaming and Gambling: A Systematic Review of Task-Specific EEG Protocols.Journal of gambling studies · 2024Pooled it
- Aversiveness of errors and the error-related negativity (ERN): A systematic review on the affective states' manipulations findings.Cognitive, affective & behavioral neuroscience · 2022Pooled it
- L-DOPA and oxytocin influence the neural correlates of performance monitoring for self and others.Psychopharmacology · 2024Trial
- Non-invasive brain stimulation modulates neural correlates of performance monitoring in patients with obsessive-compulsive disorder.NeuroImage. Clinical · 2022Trial
- Evaluating clinical and neuroimaging predictors for cognitive-behavioral therapy outcome in obsessive-compulsive disorder.Scientific reports · 2026Article
- Cerebellar GABA and executive function among adult female carriers of the fragile X messenger ribonucleoprotein 1 premutation: a pilot study to examine neural underpinnings of the clinical phenotype.Neurobiology of disease · 2026Article
- Brain rhythms of depression: A predictive processing perspective.Trends in neurosciences · 2026Review
- The association between the error-related negativity and self-control is moderated by impulsivity and compulsivity.Communications psychology · 2026Article
- Adolescent Risky Alcohol Use Is Associated With Electrophysiological Markers of Error Processing: Findings From a Large Cohort Study.Biological psychiatry global open science · 2026Article
- Working memory load-dependent modulation of neural activity predicts response to cognitive behavioral therapy in obsessive-compulsive disorder.Translational psychiatry · 2025Article
- Neuromodulation and neural networks in psychiatric disorders: current status and emerging prospects.Psychological medicine · 2025Review
- Response Monitoring Theta-Band Activities Across Emotional Contexts in Schizophrenia and Bipolar Spectrum Disorders.Biological psychiatry global open science · 2025Article
- The impact of impulsivity and compulsivity on error processing in different motivational contexts.Cognitive, affective & behavioral neuroscience · 2025Article
- Basal ganglia theta power indexes trait anxiety in people with Parkinson's disease.Brain : a journal of neurology · 2025Article
- Enhanced Performance Monitoring as a Transdiagnostic Risk Marker of the Anxiety and Obsessive-Compulsive Spectrum: The Role of Disorder Category, Clinical Status, Family Risk, and Anxiety Dimensions.Depression and anxiety · 2025Article
- Shared and Unique Structural Covariance Connectivity in Comorbidity of Obsessive-Compulsive Disorder and Major Depressive Disorder.Depression and anxiety · 2025Article
- Neural markers of error processing relate to task performance, but not to substance-related risks and problems and externalizing problems in adolescence and emerging adulthood.Developmental cognitive neuroscience · 2025Article
- A network analysis of affective and motivational individual differences and error monitoring in a non-clinical sample.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Error-related brain activity shapes the association between trait neuroticism and internalizing symptomatology in two tasks.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2024Article
- Basal ganglia theta power indexes trait anxiety in people with Parkinson's disease.medRxiv : the preprint server for health sciences · 2024Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreased neural error-signals have been observed in obsessive-compulsive disorder (OCD), anxiety disorders, and inconsistently in depression. Reduced neural error-signals have been observed in substance use disorders (SUD). Thus, alterations in error-monitoring are proposed as a transdiagnostic endophenotype. To strengthen this notion, data from unaffected individuals with a family history for the respective disorders are needed.
methodsThe error-related negativity (ERN) as a neural indicator of error-monitoring was measured during a flanker task from 117 OCD patients, 50 unaffected first-degree relatives of OCD patients, and 130 healthy comparison participants. Family history information indicated, that 76 healthy controls were free of a family history for psychopathology, whereas the remaining had first-degree relatives with depression (n = 28), anxiety (n = 27), and/or SUD (n = 27).
resultsIncreased ERN amplitudes were found in OCD patients and unaffected first-degree relatives of OCD patients. In addition, unaffected first-degree relatives of individuals with anxiety disorders were also characterized by increased ERN amplitudes, whereas relatives of individuals with SUD showed reduced amplitudes.
conclusionsAlterations in neural error-signals in unaffected first-degree relatives with a family history of OCD, anxiety, or SUD support the utility of the ERN as a transdiagnostic endophenotype. Reduced neural error-signals may indicate vulnerability for under-controlled behavior and risk for substance use, whereas a harm- or error-avoidant response style and vulnerability for OCD and anxiety appears to be associated with increased ERN. This adds to findings suggesting a common neurobiological substrate across psychiatric disorders involving the anterior cingulate cortex and deficits in cognitive control.
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