ArticleHuman genomics2019
The evolutionary genetics of lactase persistence in seven ethnic groups across the Iranian plateau.
Article in Human genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Gut microbiome composition reveals the distinctiveness between the Bengali people and the Indigenous ethnicities in Bangladesh.Communications biology · 2024Article
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- The Genetic Echo of the Tarim Mummies in Modern Central Asians.Molecular biology and evolution · 2022Article
- Correction to: The evolutionary genetics of lactase persistence in seven ethnic groups across the Iranian plateau.Human genomics · 2021Article
- Tracing the Genetic Legacy of the Tibetan Empire in the Balti.Molecular biology and evolution · 2021Article
- Genetics of Lactose Intolerance: An Updated Review and Online Interactive World Maps of Phenotype and Genotype Frequencies.Nutrients · 2020Review
- Why and when was lactase persistence selected for? Insights from Central Asian herders and ancient DNA.PLoS biology · 2020Article
- Association of Lactase Persistence Genotypes (rs4988235) and Ethnicity with Dairy Intake in a Healthy U.S. Population.Nutrients · 2019Observational
- Correction to: The evolutionary genetics of lactase persistence in seven ethnic groups across the Iranian plateau.Human genomics · 2019Article
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
8 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe ability to digest dietary lactose is associated with lactase persistence (LP) in the intestinal lumen in human. The genetic basis of LP has been investigated in many populations in the world. Iran has a long history of pastoralism and the daily consumption of dairy products; thus, we aim to assess how LP has evolved in the Iranian population. We recruited 400 adult individuals from seven Iranian ethnic groups, from whom we investigated their lactose tolerance and screened the genetic variants in their lactase gene locus.
resultsThe LP frequency distribution ranged from 0 to 29.9% in the seven Iranian ethnic groups with an average value of 9.8%. The variants, - 13910*T and - 22018*A, were significantly associated with LP phenotype in Iranians. We found no evidence of hard selective sweep for - 13910*T and - 22018*A in Persians, the largest ethnic group of Iran. The extremely low frequency of - 13915*G in the Iranian population challenged the view that LP distribution in Iran resulted from the demic diffusion, especially mediated by the spread of Islam, from the Arabian Peninsula.
conclusionsOur results indicate the distribution of LP in seven ethnic groups across the Iranian plateau. Soft selective sweep rather than hard selective sweep played a substantial role in the evolution of LP in Iranian populations.
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