Evidence map›Paper›PMID 30744657›Full record

ArticleDiagnostic pathology2019

Concurrent isolated retroperitoneal HGSC and STIC defined by somatic mutation analysis: a case report.

Kazuaki Suda, Hirofumi Nakaoka, Chihiro Hata, Natsumi Yahata, Masanori Isobe, Hitoshi Kameyama, Toshifumi Wakai, Teiichi Motoyama, Ituro Inoue, Kosuke Yoshihara and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostic pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Kazuaki SudaDepartment of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata, 951-8510, Japan.
Hirofumi NakaokaDepartment of Genetics, School of Life Sciences, Graduate University for Advanced Studies (SOKENDAI), Hayama, Japan.
Chihiro HataDepartment of Genetics, School of Life Sciences, Graduate University for Advanced Studies (SOKENDAI), Hayama, Japan.
Natsumi YahataDepartment of Obstetrics and Gynecology, Niigata Prefectural Shibata Hospital, Shibata, Japan.
Masanori IsobeDepartment of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata, 951-8510, Japan.
Hitoshi KameyamaDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Toshifumi WakaiDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Teiichi MotoyamaDepartment of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Ituro InoueDepartment of Genetics, School of Life Sciences, Graduate University for Advanced Studies (SOKENDAI), Hayama, Japan.
Kosuke YoshiharaDepartment of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata, 951-8510, Japan. yoshikou@med.niigata-u.ac.jp.ORCID http://orcid.org/0000-0002-2254-3378
Takayuki EnomotoDepartment of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata, 951-8510, Japan.
Niigata University Medical and Dental Hospital · JPNational Institute of Genetics · JPNiigata University · JPNiigata Prefectural Shibata Hospital · JP

Funding

Japan Society for the Promotion of Science JP16H06267
6 · The paper itself

Abstract

backgroundRetroperitoneal high-grade serous carcinoma (HGSC) is extremely rare and the origin remains unclear. We present a case of retroperitoneal HGSC and coexisting serous tubal intraepithelial carcinoma (STIC), which is considered as the main origin of ovarian HGSC. We reviewed the available literature and discussed about the origin of this rare disease. CASE PRESENTATION: A 58-year-old female with a 93 × 65 × 62 mm-solid tumor with a cystic part was located immediately dorsal to the rectum underwent bilateral salpingo-oophorectomy, total abdominal hysterectomy, and en bloc resection of the retroperitoneal tumor together with lower anterior resection of the rectum. Histological diagnosis was retroperitoneal HGSC and STIC at the right fallopian tube. Two deleterious somatic mutations in TP53 and BRCA2 genes were shared between retroperitoneal HGSC and STIC.

conclusionsIn addition to clinical features in the previous reports, our genetic findings suggest the origin of retroperitoneal HGSC might be STIC.

Indexed as

BRCA2 ProteinCarcinoma in SituCystadenocarcinoma, SerousDNA Mutational AnalysisFallopian Tube NeoplasmsFemaleHumansMiddle AgedMutationNeoplasms, Second PrimaryRetroperitoneal NeoplasmsTumor Suppressor Protein p53BRCA2 ProteinBRCA2 protein, humanTP53 protein, humanTumor Suppressor Protein p53Case reportRetroperitoneal high-grade serous carcinomaSerous tubal intraepithelial carcinomaSomatic mutation

Identifiers

PMID30744657
PMCPMC6371506
OpenAlexW2922247668

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.