SynthesisFluids and barriers of the CNS2019
Comorbidity of diabetes mellitus in idiopathic normal pressure hydrocephalus: a systematic literature review.
Synthesis in Fluids and barriers of the CNS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Shunting for idiopathic normal pressure hydrocephalus.The Cochrane database of systematic reviews · 2024Pooled it
- Vascular risk factors for idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis.Frontiers in neurology · 2023Pooled it
- Impact of SGLT2 inhibitors on cerebrospinal fluid dynamics and implications for hydrocephalus management.The Journal of clinical investigation · 2025Article
- A protocol for a cohort study investigating clinical and radiological features of normal pressure hydrocephalus in South London memory services.Wellcome open research · 2025Article
- Ventriculoperitoneal shunt patients and glaucoma: a cohort analysis of the NPH registry.Fluids and barriers of the CNS · 2024Article
- Modeling cerebrospinal fluid dynamics across the entire intracranial space through integration of four-dimensional flow and intravoxel incoherent motion magnetic resonance imaging.Fluids and barriers of the CNS · 2024Article
- 10-year mortality, causes of death and cardiovascular comorbidities in idiopathic normal pressure hydrocephalus.Journal of neurology · 2024Article
- Association between telomere length and idiopathic normal pressure hydrocephalus: a Mendelian randomization study.Frontiers in neurology · 2024Article
- High prevalence of lumbar spinal stenosis in cases of idiopathic normal-pressure hydrocephalus affects improvements in gait disturbance after shunt operation.World neurosurgery: X · 2023Article
- Ependymal cells SCOre sweet cerebrospinal fluid.PLoS biology · 2023Article
- Association between vascular risk factors and idiopathic normal pressure hydrocephalus: a Mendelian randomization study.Journal of neurology · 2023Article
- Exploring mechanisms of ventricular enlargement in idiopathic normal pressure hydrocephalus: a role of cerebrospinal fluid dynamics and motile cilia.Fluids and barriers of the CNS · 2021Review
- Molecular Mechanisms and Risk Factors for the Pathogenesis of Hydrocephalus.Frontiers in genetics · 2021Review
- Diabetes is associated with familial idiopathic normal pressure hydrocephalus: a case-control comparison with family members.Fluids and barriers of the CNS · 2020Article
- This was the year that was: brain barriers and brain fluid research in 2019.Fluids and barriers of the CNS · 2020Article
- Impact of Comorbidities and Frailty on Early Shunt Failure in Geriatric Patients With Normal Pressure Hydrocephalus.Frontiers in medicine · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Idiopathic normal pressure hydrocephalus (iNPH) is a subtype of hydrocephalus that occurs more often in the elderly population. It is usually characterized by gait disturbance, dementia and urinary incontinence. Epidemiological studies indicate that 15.7-17.8% of iNPH patients present with type-2 diabetes mellitus (DM). A review of the primary literature shows that these occurrence rates are higher than age- and cohort-matched non-iNPH controls. This suggests that this already vulnerable patient group has an increased risk for presenting with DM compared to their non-iNPH counterparts. Postoperative outcome when treating iNPH patients is inversely related to the number of patient comorbidities and a lower comorbidity status is correlated with better outcomes. This review highlights the need for further research into the relationship between iNPH and DM and speculates on a possible mechanism for an association between the development of ventriculomegaly and the development of DM and iNPH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.