Evidence map›Paper›PMID 30744621›Full record

Trial reportBMC public health2019

Effect of diet with or without exercise on abdominal fat in postmenopausal women - a randomised trial.

Willemijn A van Gemert, Petra H Peeters, Anne M May, Adriaan J H Doornbos, Sjoerd G Elias, Job van der Palen, Wouter Veldhuis, Maaike Stapper, Jantine A Schuit, Evelyn M Monninkhof

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01511276 (The Effects of Equivalent Weight Loss With or Without Exercise Training on Breast Cancer Risk Biomarkers in Postmenopausal Women), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01511276 nacompletednot on this map

The Effects of Equivalent Weight Loss With or Without Exercise Training on Breast Cancer Risk Biomarkers in Postmenopausal Women: the SHAPE-2 Study

TypeinterventionalSponsorUMC UtrechtRan2012 to 2014Enrolled243ConditionsBreast Cancer RiskArmsDiet, Mainly exercise induced weight loss
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Obesity and Breast Cancer Risk: The Oncogenic Implications of Metabolic Dysregulation.The Journal of clinical endocrinology and metabolism · 2022
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  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Willemijn A van GemertDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, STR 6.131, Universiteitsweg 100, 3584 CG, Utrecht, the Netherlands.
Petra H PeetersDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, STR 6.131, Universiteitsweg 100, 3584 CG, Utrecht, the Netherlands.
Anne M MayDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, STR 6.131, Universiteitsweg 100, 3584 CG, Utrecht, the Netherlands.
Adriaan J H DoornbosDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, STR 6.131, Universiteitsweg 100, 3584 CG, Utrecht, the Netherlands.
Sjoerd G EliasDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, STR 6.131, Universiteitsweg 100, 3584 CG, Utrecht, the Netherlands.
Job van der PalenMedisch Spectrum Twente Hospital, Department of Epidemiology, Enschede, the Netherlands.
Wouter VeldhuisDepartment of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Maaike StapperDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, STR 6.131, Universiteitsweg 100, 3584 CG, Utrecht, the Netherlands.
Jantine A SchuitDivision of Public Health and Health Care, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
Evelyn M MonninkhofDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, STR 6.131, Universiteitsweg 100, 3584 CG, Utrecht, the Netherlands. e.monninkhof@umcutrecht.nl.ORCID http://orcid.org/0000-0002-6641-7605

Funding

National Key Research and Development Program of China 2017YFD0500804National Natural Science Foundation of China 31802222Natural Science Foundation of Jiangsu Province BK20160064
6 · The paper itself

Abstract

backgroundWe assessed the effect of equivalent weight loss with or without exercise on (intra-) abdominal fat in postmenopausal women in the SHAPE-2 study.

methodsThe SHAPE-2 study is a three-armed randomised controlled trial conducted in 2012-2013 in the Netherlands. Postmenopausal overweight women were randomized to a diet (n = 97), exercise plus diet (n = 98) or control group (n = 48). Both intervention groups aimed for equivalent weight loss (6-7%) following a calorie-restricted diet (diet group) or a partly supervised intensive exercise programme (4 h per week) combined with a small caloric restriction (exercise plus diet group). Outcomes after 16 weeks are amount and distribution of abdominal fat, measured by magnetic resonance imaging (MRI) with the use of the three-point IDEAL Dixon method.

resultsThe diet and exercise plus diet group lost 6.1 and 6.9% body weight, respectively. Compared to controls, subcutaneous and intra-abdominal fat reduced significantly with both diet (- 12.5% and - 12.0%) and exercise plus diet (- 16.0% and - 14.6%). Direct comparison between both interventions revealed that the reduction in subcutaneous fat was statistically significantly larger in the group that combined exercise with diet: an additional 10.6 cm

conclusionsWe conclude that weight loss of 6-7% with diet or with exercise plus diet reduced both subcutaneous and intra-abdominal fat. Only subcutaneous fat statistically significantly reduced to a larger extent when exercise is combined with a small caloric restriction. TRIAL REGISTER: NCT01511276 (clinicaltrials.gov), prospectively registered.

Indexed as

Abdominal FatCaloric RestrictionExercisePostmenopauseAgedFemaleHumansMiddle AgedNetherlandsObesityOverweightProgram EvaluationWeight Reduction ProgramsExerciseIntra-abdominal fatSubcutaneous fatWeight loss

Identifiers

PMID30744621
PMCPMC6371569

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.