Evidence map›Paper›PMID 30744613›Full record

ArticleBMC health services research2019

An empirical tool for estimating the share of unmet need due to healthcare inefficiencies, suboptimal access, and lack of effective technologies.

Devin Incerti, John Browne, Caroline Huber, Christine L Baker, Geoff Makinson, Amir Goren, Richard Willke, Warren Stevens

Abstract read
In one paragraph

Article in BMC health services research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Unmet health-related needs in patients with Crohn's disease in Belgium: a mixed-methods study.Archives of public health = Archives belges de sante publique · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Devin IncertiPrecision Health Economics, 11100 Santa Monica Blvd #500, Los Angeles, CA, 90025, USA. Devin.Incerti@PrecisionHealthEconomics.com.ORCID http://orcid.org/0000-0002-4479-8750
John BrowneUniversity College Cork, College Rd, University College, Cork, Ireland.
Caroline HuberPrecision Health Economics, 11100 Santa Monica Blvd #500, Los Angeles, CA, 90025, USA.
Christine L BakerPfizer, Inc., 235 E 42nd St, New York, NY, 10017, USA.
Geoff MakinsonPfizer, Inc., 235 E 42nd St, New York, NY, 10017, USA.
Amir GorenKantar Health, 11 Madison Ave # 12, New York, NY, 10010, USA.
Richard WillkeInternational Society for Pharmacoeconomics and Outcomes Research, 505 Lawrence Square Blvd, South Lawrenceville, NJ, 08648, USA.
Warren StevensParexel International, 2520 Meridian Parkway, Durham, NC, 27713, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough there has been growing attention to the measurement of unmet need, which is the overall epidemiological burden of disease, current measures ignore the burden that could be eliminated from technological advances or more effective use of current technologies.

methodsWe developed a conceptual framework and empirical tool that separates unmet need from met need and subcategorizes the causes of unmet need into suboptimal access to and ineffective use of current technologies and lack of current technologies. Statistical models were used to model the relationship between health-related quality of life (HR-QOL) and treatment utilization using data from the National Health and Wellness Survey (NHWS). Predicted HR-QOL was combined with prevalence data from the Global Burden of Disease Study (GBD) to estimate met need and the causes of unmet need due to morbidity in the US and EU5 for five diseases: rheumatoid arthritis, breast cancer, Parkinson's disease, hepatitis C, and chronic obstructive pulmonary disease (COPD).

resultsHR-QOL was positively correlated with adherence to medication and patient-perceived quality and negatively correlated with financial barriers. Met need was substantial across all disease and regions, although significant unmet need remains. While the majority of unmet need was driven by lack of technologies rather than ineffective use of current technologies, there was considerable variation across diseases and regions. Overall unmet need was largest for COPD, which had the highest prevalence of all diseases in this study.

conclusionWe developed a methodology that can inform decisions about which diseases to invest in and whether those investments should focus on improving access to currently available technologies or inventing new technologies.

Indexed as

Quality of LifeAdolescentAdultAgedBiomedical TechnologyDelivery of Health CareFemaleHealthcare DisparitiesHumansMaleMiddle AgedNeeds AssessmentPatient Acceptance of Health CarePrevalenceQuality of Health CareYoung AdultAccess to healthcareHealthcare inefficiencyHealth economicsInequalityQuality of lifeUnmet need

Identifiers

PMID30744613
PMCPMC6371562

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.