ArticleBMC microbiology2019
Biological characterization of Pasteurella multocida present in the Saiga population.
Article in BMC microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 39 citations in OpenAlex.
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- Comparative analysis of shared and unique mechanisms important for diverse strains of Pasteurella multocida to cause systemic infection in mice.PLoS pathogens · 2025Article
- Development and characterization of antibodies againstOpen veterinary journal · 2025Article
- Hemorrhagic septicemia: A major threat to livestock health.Open veterinary journal · 2025Review
- Molecular Detection and Antibiogram Profiling ofInternational journal of microbiology · 2025Article
- Fowl Cholera in Chickens: Current Trends in Diagnosis and Phenotypic Drug Resistance in Gondar City, Ethiopia.Veterinary medicine international · 2024Review
- A Comprehensive Review of the Common Bacterial Infections in Dairy Calves and Advanced Strategies for Health Management.Veterinary medicine (Auckland, N.Z.) · 2024Review
- A survey of the parasites of Ural saiga antelopes and Turkmenian kulans of Kazakhstan.International journal for parasitology. Parasites and wildlife · 2023Article
- Global commercialization and research of veterinary vaccines againstVeterinary world · 2023Article
- The Immunoprotection ofVeterinary sciences · 2023Article
- Wild animal and zoonotic disease risk management and regulation in China: Examining gaps and One Health opportunities in scope, mandates, and monitoring systems.One health (Amsterdam, Netherlands) · 2021Review
- Re-Emergence and Spread of Haemorrhagic Septicaemia in Germany: The Wolf as a Vector?Microorganisms · 2021Article
- Zoonotic diseases appeared to be a major hurdle to successful deer farming in Bangladesh.Veterinary world · 2021Article
- Draft Genome Sequences of Three Pasteurella multocida Strains Isolated from Domestic Animals in Kazakhstan.Microbiology resource announcements · 2020Article
- Article
- Mass Die-Off of Saiga Antelopes, Kazakhstan, 2015.Emerging infectious diseases · 2019Article
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study provides biochemical and molecular genetic characteristics of P. multocida isolated from dead saigas in 1988, 2010-2015 on the territory of the Republic of Kazakhstan.
resultsBacteriological samples taken from carcasses of saiga antelope during mortality events recorded in West Kazakhstan in both 2010 and 2011 and in Kostanay in 2012 and 2015 confirmed the presence of P. multocida, according to morphological and biochemical characterisation. Only in the event of 2015 was the agent proven to be the causative agent of the disease observed, haemorrhagic septicaemia. In the other mortality events it is not certain if the organism was a primary aetiology or an incidental finding as confirmatory pathological investigation was not undertaken. The implemented phylogenetic analysis of ribosomal RNA 16S gene allowed us to identify Pasteurella strains isolated in 2010-2015 as P. multocida subspecies multocida. Capsular typing by PCR showed that the studied strains isolated from dead saiga in 2010, 2011, 2012 and 2015 belonged to serotype B. MLST analysis showed that these strains of P. multocida are of the capsule type B and form one clonal grouping with isolates ST64, ST44, ST45, ST46, ST44, ST47 which isolated from cases of hemorrhagic septicemia of animals in Hungary, Burma, Sri Lanka, Pakistan and Spain. Sixteen virulence genes of the five strains of P. multocida, isolated from saigas were studied using multiplex PCR. ptfA, ompA, ompH, oma87, plpB, fimA, hsf-2, pfhA, exbB, tonB, hgbA, fur, nanB, nanH and pmHAS genes were detected in all strains. The toxA gene was not identified in the studied strains. The phylogenies of these isolates is compared across saiga populations and years and the 2015 isolate was compared to that of an isolate from a disease outbreak in 1988 and the findings suggest that these isolated bacteria are stable commensals, opportunistically pathogenic, being phylogenetically uniform with very little genetic variation notable over the last 4 decades.
conclusionIsolation, phenotypic and genetic characterization of the P. multocida isolates inform understanding of the epidemiology of infection in saigas and predict virulent potential of these opportunistic bacteria.
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