Evidence map›Paper›PMID 30744474›Full record

ArticleJournal of feline medicine and surgery2020

Sedative and physiologic effects of tiletamine-zolazepam following buccal administration in cats.

Pablo Nejamkin, Verónica Cavilla, María Clausse, Florencia Landivar, Augusto M Lorenzutti, Sofía Martínez, María J Del Sole, Manuel Martín-Flores

Open access · greenAbstract readRandomized Controlled Trial, Veterinary
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of feline medicine and surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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  6. Feline procedural sedation and analgesia: When, why and how.Journal of feline medicine and surgery · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Pablo NejamkinHospital for Small Animals, Faculty of Veterinary Sciences, National Central University of the Province of Buenos Aires, University Campus, Tandil, Argentina.ORCID 0000-0001-6460-3327
Verónica CavillaSmall Animal Medicine and Surgery, Clinical Department, Faculty of Veterinary Sciences, National Central University of the Province of Buenos Aires, University Campus, Tandil, Argentina.
María ClausseGeneral Clinical Surgery Department, Faculty of Veterinary Sciences, National Central University of the Province of Buenos Aires, University Campus, Tandil, Argentina.
Florencia LandivarHospital for Large Animals, Faculty of Veterinary Sciences, National Central University of the Province of Buenos Aires, University Campus, Tandil, Argentina.
Augusto M LorenzuttiPharmacology and Toxicology, Faculty of Agricultural Sciences, Catholic University of Córdoba, Córdoba, Argentina.
Sofía MartínezSmall Animal Medicine and Surgery, Clinical Department, Faculty of Veterinary Sciences, National Central University of the Province of Buenos Aires, University Campus, Tandil, Argentina.
María J Del SoleHospital for Large Animals, Faculty of Veterinary Sciences, National Central University of the Province of Buenos Aires, University Campus, Tandil, Argentina.
Manuel Martín-FloresDepartment of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
Universidad Nacional del Centro de la Provincia de Buenos Aires · ARConsejo Nacional de Investigaciones Científicas y Técnicas · ARCornell University · USUniversidad Católica de Córdoba · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study was to describe the sedative and some physiological effects of tiletamine-zolazepam following buccal administration (BA) in cats.

methodsSeven healthy spayed European shorthair cats (three males, four females) were studied twice in this randomized, blinded, crossover study. Each cat received two doses of tiletamine-zolazepam by BA: the low-dose (LD) group consisted of 5 mg/kg of each drug, and the high-dose (HD) group consisted of 7.5 mg/kg of each. Baseline systolic blood pressure (SAP), heart rate (HR), respiratory rate (RR) and a sedation score were recorded prior to administration of each treatment. The same variables plus the percentage of hemoglobin saturated with oxygen as measured by pulse oximetry (SpO

resultsAll cats completed the study. No retching or vomiting were observed. Hypersalivation was observed in 0/7 and 3/7 for LD and HD groups, respectively ( CONCLUSIONS AND RELEVANCE: BA of tiletamine-zolazepam at the doses studied here is a simple and effective method for chemical restraint in cats, where the LD group had a lower impact on SAP and RR than the HD group.

Indexed as

Hypnotics and SedativesTiletamineZolazepamAdministration, BuccalAnimalsCatsCross-Over StudiesDrug CombinationsFemaleHeart RateMaleProcedural SedationRespiratory RateDrug CombinationsHypnotics and SedativesTiletaminetiletamine, zolazepam drug combinationZolazepambuccal administrationchemical restraintphysiological variablesTiletamine–zolazepam

Identifiers

PMID30744474
PMCPMC10814565
OpenAlexW2912947323

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.