Evidence map›Paper›PMID 30744440›Full record

ArticleDrug delivery2019

Efficient exosome delivery in refractory tissues assisted by ultrasound-targeted microbubble destruction.

Wenqi Sun, Zhelong Li, Xueying Zhou, Guodong Yang, Lijun Yuan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 80 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wenqi Suna Department of Ultrasound Diagnostics , Tangdu Hospital Fourth Military Medical University , Xi'an, People's Republic of China.
Zhelong Lia Department of Ultrasound Diagnostics , Tangdu Hospital Fourth Military Medical University , Xi'an, People's Republic of China.
Xueying Zhoua Department of Ultrasound Diagnostics , Tangdu Hospital Fourth Military Medical University , Xi'an, People's Republic of China.
Guodong Yangb The State Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology , Fourth Military Medical University , Xi'an, People's Republic of China.
Lijun Yuana Department of Ultrasound Diagnostics , Tangdu Hospital Fourth Military Medical University , Xi'an, People's Republic of China.
Air Force Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, exosomes have been emerged as promising drug delivery carriers, while certain tissues are intrinsically resistant to exosomes. Therapeutically improving the drug delivery efficiency in these tissues/organs would certainly broaden the potential application of exosomes in future. Ultrasound-targeted microbubble destruction (UTMD) is a promising technique for non-invasive, targeted drug delivery. In this study, we explore the possibility that UTMD assists exosome delivery in these intrinsically resistant tissues. Mice were subjected to tail vein injection of DiR-labeled exosomes together with/without UTMD of SonoVue

Indexed as

MicrobubblesUltrasonic WavesAnimalsCells, CulturedDrug Delivery SystemsExosomesMaleMiceMice, Inbred C57BLMicroscopy, FluorescenceTissue DistributionefficiencyexosomesmicrobubblesTargeted drug deliveryultrasound-targeted microbubble destruction

Identifiers

PMID30744440
PMCPMC6374922
OpenAlexW2913398462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.