Evidence map›Paper›PMID 30744430›Full record

Trial reportBiomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals2019

Bronchoalveolar fluid and plasma inflammatory biomarkers in contemporary ARDS patients.

Renee D Stapleton, Benjamin T Suratt, Margaret J Neff, Mark M Wurfel, Lorraine B Ware, John T Ruzinski, Ellen Caldwell, Teal S Hallstrand, Polly E Parsons

Registry-linked trialAbstract readClinical Trial, Phase IIRandomized Controlled Trial
In one paragraph

Trial report in Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06067152 (REcruitment MAneuvers and Mechanical Ventilation Guided by EIT in Pediatric Acute Respiratory Distress Syndrome), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06067152 naunknown statusnot on this mapstarted 2022, after this paper: background citation

REcruitment MAneuvers and Mechanical Ventilation Guided by EIT in Pediatric Acute Respiratory Distress Syndrome (pARDS)

TypeinterventionalSponsorFondazione IRCCS Ca' Granda, Ospedale Maggiore PoliclinicoRan2022 to 2024Enrolled13ConditionsARDS, Pediatric Respiratory Distress Syndrome, Respiratory DiseaseArmsEIT measurement, Staircase Recruitment Maneuvers with EIT guided and decremental PEEP trial, Setting of EIT-guided mechanical ventilation, Reevaluation after 24 h
3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Chemokines, soluble PD-L1, and immune cell hyporesponsiveness are distinct features of SARS-CoV-2 critical illness.American journal of physiology. Lung cellular and molecular physiology · 2022
    Article
  8. Article
  9. Article
  10. Characterization of the Inflammatory Response to Severe COVID-19 Illness.American journal of respiratory and critical care medicine · 2020
    Article
  11. Article
  12. Dapsone as treatment adjunct in ARDS.Experimental lung research
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Renee D Stapletona Department of Medicine, Division of Pulmonary and Critical Care Medicine , University of Vermont College of Medicine , Burlington , VT , USA.
Benjamin T Suratta Department of Medicine, Division of Pulmonary and Critical Care Medicine , University of Vermont College of Medicine , Burlington , VT , USA.
Margaret J Neffb Department of Medicine , Stanford University , Palo Alto , CA , USA.
Mark M Wurfelc Department of Medicine, Division of Pulmonary and Critical Care Medicine , University of Washington , Seattle , WA , USA.
Lorraine B Wared Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine , Vanderbilt University , Nashville , TN , USA.
John T Ruzinskic Department of Medicine, Division of Pulmonary and Critical Care Medicine , University of Washington , Seattle , WA , USA.
Ellen Caldwellc Department of Medicine, Division of Pulmonary and Critical Care Medicine , University of Washington , Seattle , WA , USA.
Teal S Hallstrandc Department of Medicine, Division of Pulmonary and Critical Care Medicine , University of Washington , Seattle , WA , USA.
Polly E Parsonsa Department of Medicine, Division of Pulmonary and Critical Care Medicine , University of Vermont College of Medicine , Burlington , VT , USA.

Funding

WEIGHT LOSS & ASTHMAP20RR015557 · NCRR · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI LUNDBLAD, LENNART KARL ALF · 2000 to 2009
$21.4M
SCCOR in Translational Research in Acute Lung InjuryP50HL073996 · NHLBI · UNIVERSITY OF WASHINGTON · PI MARTIN, THOMAS R · 2003 to 2007
$15.7M
UW Multidisciplinary Clinical Research Training (RMI)K12RR023265 · NCRR · UNIVERSITY OF WASHINGTON · PI PROBSTFIELD, JEFFREY LYNN · 2005 to 2007
$6.1M
Pharmaconutrients as Therapies for Critical Illness: Zinc in Severe SepsisK23HL105654 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI STAPLETON, RENEE D · 2011 to 2014
$626k
NCRR NIH HHS K12 RR023265NCRR NIH HHS P20 RR015557NHLBI NIH HHS K23 HL105654NHLBI NIH HHS P50 HL073996
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAgedAntigens, NeoplasmBiomarkersBronchoalveolar Lavage FluidChemokine CCL2Fas Ligand ProteinFemaleGranulocyte Colony-Stimulating FactorHumansInterleukin-10Interleukin-1betaInterleukin-6Interleukin-8Leukocyte CountLeukotriene B4Antigens, NeoplasmBiomarkersCCL2 protein, humanChemokine CCL2CXCL8 protein, humanFas Ligand ProteinGranulocyte Colony-Stimulating FactorIL10 protein, humanIL1B protein, humanIL6 protein, humanInterleukin-10Interleukin-1betaInterleukin-6Interleukin-8Leukotriene B4Mitogen-Activated Protein KinasesMOK protein, humanPulmonary Surfactant-Associated Protein DTumor Necrosis Factor-alphavon Willebrand FactorAcute respiratory distress syndrome (ARDS)bronchoalveolar lavagecritical illnessinflammatory mediatorsplasmarespiratory failure

Identifiers

PMID30744430
PMCPMC7147943

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.