ArticleEthics & human research2019
Advancing Ethics and Policy for Healthy-Volunteer Research through a Model-Organism Framework.
Article in Ethics & human research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Healthy participant engagement in early clinical trials: results from the European EUFEMED survey.Frontiers in pharmacology · 2025Article
- The VolREthics initiative to protect the well-being of healthy volunteers in biomedical research.Nature medicine · 2023Article
- Co-producing Human and Animal Experimental Subjects: Exploring the Views of UK COVID-19 Vaccine Trial Participants on Animal Testing.Science, technology & human values · 2023Article
- Ethical Criteria for Improved Human Subject Protections in Phase I Healthy Volunteer Trials.Ethics & human research · 2022Article
- Phase I trial compensation: How much do healthy volunteers actually earn from clinical trial enrollment?Clinical trials (London, England) · 2021Article
- Speculating on Precarious Income: Finance Cultures and the Risky Strategies of Healthy Volunteers in Clinical Drug Trials.Journal of cultural economy · 2021Article
- Appraising Harm in Phase I Trials: Healthy Volunteers' Accounts of Adverse Events.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2019Article
- "My Body is One of the Best Commodities": Exploring the Ethics of Commodification in Phase I Healthy Volunteer Clinical Trials.Kennedy Institute of Ethics journal · 2019Article
- Mission Creep or Mission Lapse? Scientific Review in Research Oversight.AJOB empirical bioethicsArticle
- Exclusion of Women from Phase I Trials: Perspectives from Investigators and Research Oversight Officials.Ethics & human researchArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Nonhuman animal research and phase I healthy-volunteer clinical trials are both critical components of testing the safety of investigational drugs as part of the development of new pharmaceuticals. In addition, these types of research share important structural features, as both take place in confinement and both use subjects that are dissimilar to the target population. By mobilizing a model-organism framework for phase I trials, we employ concepts and mechanisms typical to animal research to query gaps in the human subjects ethics and policy framework. By bringing these two research worlds together, we aim to illustrate how the model-organism framework can enhance healthy volunteers' welfare during trials, improve research oversight, and more critically assess the science value of current phase I trials.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.