ReviewCancers2019
Mechanistic Modelling of Radiation Responses.
Review in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- A neural network embedding the linear-quadratic model for improved prediction of cellular response to ion beam exposure.Scientific reports · 2026Article
- Investigation of relative biological effectiveness for protons, carbon and oxygen ion beams by DNA damage calculations in a fractal fibroblast cell geometry.Radiological physics and technology · 2026Article
- Predicting DNA damage yields and assessing beam quality for protons and carbon ions using a DBSCAN algorithm.Scientific reports · 2026Article
- Low-Dose radiation risk in medicine: a look at risk models, challenges, and future prospects.Zeitschrift fur medizinische Physik · 2025Review
- Microdosimetry calculations in situ for clinically relevant photon sources and their correlation with the early DNA damage response.Medical physics · 2025Article
- The temporal response of a glioma cell population to irradiation: modelling the effect of dose and cell density.Royal Society open science · 2025Article
- Modeling of chemo-radiotherapy targeting growing vascular tumors: A continuum-level approach.PloS one · 2025Article
- Historical view of the effects of radiation on cancer cells.Oncology reviews · 2025Review
- Molecular Insights into Radiation Effects and Protective Mechanisms: A Focus on Cellular Damage and Radioprotectors.Current issues in molecular biology · 2024Review
- Biological effective dose as a predictor of local tumor control in stereotactic radiosurgery treated parasellar meningioma patients.Journal of neuro-oncology · 2024Article
- A mechanistic simulation of induced DNA damage in a bacterial cell by X- and gamma rays: a parameter study.Physical and engineering sciences in medicine · 2024Article
- Prediction of Cell Survival Rate Based on Physical Characteristics of Heavy Ion Radiation.Toxics · 2024Article
- A review of mechanistic learning in mathematical oncology.Frontiers in immunology · 2024Review
- Monte Carlo methods to assess biological response to radiation in peripheral organs and in critical organs near the target.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2024Review
- High-LET radiation induces large amounts of rapidly-repaired sublethal damage.Scientific reports · 2023Article
- An empirical model of proton RBE based on the linear correlation between x-ray and proton radiosensitivity.Medical physics · 2022Article
- Mass Transport Model of Radiation Response: Calibration and Application to Chemoradiation for Pancreatic Cancer.International journal of radiation oncology, biology, physics · 2022Article
- Article
- RadSigBench: a framework for benchmarking functional genomics signatures of cancer cell radiosensitivity.Briefings in bioinformatics · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiobiological modelling has been a key part of radiation biology and therapy for many decades, and many aspects of clinical practice are guided by tools such as the linear-quadratic model. However, most of the models in regular clinical use are abstract and empirical, and do not provide significant scope for mechanistic interpretation or making predictions in novel cell lines or therapies. In this review, we will discuss the key areas of ongoing mechanistic research in radiation biology, including physical, chemical, and biological steps, and review a range of mechanistic modelling approaches which are being applied in each area, highlighting the possible opportunities and challenges presented by these techniques.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.