Evidence map›Paper›PMID 30744184›Full record

ArticleInternational journal of molecular sciences2019

Mechanisms of Toxicity of Industrially Relevant Silicomanganese Dust on Human 1321N1 Astrocytoma Cells: An In Vitro Study.

Yke Jildouw Arnoldussen, Torunn Kringlen Ervik, Johanna Samulin Erdem, Ida Kero, Mina Baarnes Eriksen, Vidar Skaug, Shanbeh Zienolddiny

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yke Jildouw ArnoldussenDepartment of Biological and Chemical Work Environment, National Institute of Occupational Health, Pb 8149 Dep., N-0033 Oslo, Norway. yke.j.arnoldussen@stami.no.
Torunn Kringlen ErvikDepartment of Biological and Chemical Work Environment, National Institute of Occupational Health, Pb 8149 Dep., N-0033 Oslo, Norway. torunn.ervik@stami.no.
Johanna Samulin ErdemDepartment of Biological and Chemical Work Environment, National Institute of Occupational Health, Pb 8149 Dep., N-0033 Oslo, Norway. johanna.samulin-erdem@stami.no.
Ida KeroDepartment of Industrial Process, Technology SINTEF Materials and Chemistry, PB 4760, N-7465 Trondheim, Norway. ida.kero@sintef.no.ORCID 0000-0003-0774-2237
Mina Baarnes EriksenDepartment of Biological and Chemical Work Environment, National Institute of Occupational Health, Pb 8149 Dep., N-0033 Oslo, Norway. mina.eriksen@stami.no.
Vidar SkaugDepartment of Biological and Chemical Work Environment, National Institute of Occupational Health, Pb 8149 Dep., N-0033 Oslo, Norway. vidar.skaug@stami.no.
Shanbeh ZienolddinyDepartment of Biological and Chemical Work Environment, National Institute of Occupational Health, Pb 8149 Dep., N-0033 Oslo, Norway. shan.zienolddiny@stami.no.ORCID 0000-0001-9747-9625
National Institute of Occupational Health · NOSINTEF · NO

Funding

Norges Forskningsråd 245216 O70
6 · The paper itself

Abstract

Tremendous efforts are applied in the ferroalloy industry to control and reduce exposure to dust generated during the production process, as inhalable Mn-containing particulate matter has been linked to neurodegenerative diseases. This study aimed to investigate the toxicity and biological effects of dust particles from laboratory-scale processes where molten silicomanganese (SiMn) was exposed to air, using a human astrocytoma cell line, 1321N1, as model system. Characterization of the dust indicated presence of both nano-sized and larger particles averaging between 100 and 300 nm. The dust consisted mainly of Si, Mn and O. Investigation of cellular mechanisms showed a dose- and time-dependent effect on cell viability, with only minor changes in the expression of proteins involved in apoptosis. Moreover, gene expression of the neurotoxic biomarker

Indexed as

DustAntineoplastic AgentsAstrocytomaCell Line, TumorCell SurvivalHumansManganeseNanotechnologyOccupational ExposureSilicon CompoundsAntineoplastic AgentsDustManganeseSilicon Compoundsnanotechnologyneurotoxicityoccupationalsilicomanganese

Identifiers

PMID30744184
PMCPMC6386893
OpenAlexW2914762981

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.