Evidence map›Paper›PMID 30744145›Full record

ArticleMolecules (Basel, Switzerland)2019

Total Phenols from Grape Leaves Counteract Cell Proliferation and Modulate Apoptosis-Related Gene Expression in MCF-7 and HepG2 Human Cancer Cell Lines.

Selma Ferhi, Sara Santaniello, Sakina Zerizer, Sara Cruciani, Angela Fadda, Daniele Sanna, Antonio Dore, Margherita Maioli, Guy D'hallewin

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 63 citations in OpenAlex.

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  10. Valorization of grape (Frontiers in chemistry · 2023
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  11. Proapoptotic and Antiproliferative Effects of the Desert TruffleEvidence-based complementary and alternative medicine : eCAM · 2023
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  15. Antiviral Activity ofViruses · 2021
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  20. New Insights into the Exploitation ofAntioxidants (Basel, Switzerland) · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Selma FerhiDepartment of Applied Biology, University Larbi Tébessi Tebessa, 12000 Tebessa, Algeria. s_ferhi@yahoo.fr.
Sara SantanielloDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy. sara.santaniello@gmail.com.ORCID 0000-0003-0805-0478
Sakina ZerizerLaboratoire d'Obtention de Substances Thérapeutiques (L.O.S.T.), Département de Biologie Animale, Université Des Frères Mentouri-Constantine, 25000 Constantine, Algeria. zerizer.sakina@umc.edu.dz.
Sara CrucianiDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy. sara.cruciani@outlook.com.
Angela FaddaInstitute of Sciences of Food Production, National Research Council, Traversa la Crucca, 3. Loc Baldinca Li Punti, 07100 Sassari, Italy. angela.fadda@cnr.it.ORCID 0000-0002-1384-5956
Daniele SannaInstitute of Biomolecular Chemistry, National Research Council, Traversa La Crucca, 3. Località Baldinca Li Punti, 07100 Sassari, Italy. Daniele.Sanna@cnr.it.ORCID 0000-0001-9299-0141
Antonio DoreInstitute of Sciences of Food Production, National Research Council, Traversa la Crucca, 3. Loc Baldinca Li Punti, 07100 Sassari, Italy. antonio.dore@cnr.it.
Margherita MaioliDepartment of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy. mmaioli@uniss.it.ORCID 0000-0003-0187-4968
Guy D'hallewinInstitute of Sciences of Food Production, National Research Council, Traversa la Crucca, 3. Loc Baldinca Li Punti, 07100 Sassari, Italy. guy.dhallewin@cnr.it.
Institute of Sciences of Food Production · ITUniversity of Sassari · ITNational Research Council · ITUniversité Larbi Tébessi · DZUniversity Frères Mentouri Constantine 1 · DZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Grape leaves influence several biological activities in the cardiovascular system, acting as antioxidants. In this study, we aimed at evaluating the effect of ethanolic and water extracts from grape leaves grown in Algeria, obtained by accelerator solvent extraction (ASE), on cell proliferation. The amount of total phenols was determined using the modified Folin-Ciocalteu method, antioxidant activities were evaluated by the 2,2-diphenyl-l-picrylhydrazyl free radical (DPPH*) method and

Indexed as

AntioxidantsApoptosisCell ProliferationGene Expression Regulation, NeoplasticHep G2 CellsHumansHuman Umbilical Vein Endothelial CellsInhibitory Concentration 50MCF-7 CellsPhenolsPlant ExtractsPlant LeavesVitisAntioxidantsPhenolsPlant ExtractsAntioxidant activitiesAntiproliferativeASEGene expressiongrape leavesNutraceuticalspro-apoptotic effectsTP

Identifiers

PMID30744145
PMCPMC6384979
OpenAlexW2914469020

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.