ArticleViruses2019
A New Genotype of Feline Morbillivirus Infects Primary Cells of the Lung, Kidney, Brain and Peripheral Blood.
Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Molecular detection of feline viruses in free-ranging European wildcats (Felis s. silvestris) of the Harz Mountains, Germany.Archives of virology · 2026Article
- Pathological alteration and caspase-dependent activity of feline kidneys in natural infection of feline morbillivirus.BMC veterinary research · 2025Article
- Feline Morbillivirus: Clinical Relevance of a Widespread Endemic Viral Infection of Cats.Viruses · 2023Review
- Genetic Diversity and Evolution of Viruses InfectingViruses · 2023Review
- FeMV is a cathepsin-dependent unique morbillivirus infecting the kidneys of domestic cats.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- In Vitro Growth, Receptor Usage and Pathogenesis of Feline Morbillivirus in the Natural Host.Viruses · 2022Article
- Feline Morbillivirus in Southern Italy: Epidemiology, Clinico-Pathological Features and Phylogenetic Analysis in Cats.Viruses · 2021Article
- Review
- Article
- High seroprevalence of feline morbilliviruses in free-roaming domestic cats in Chile.Archives of virology · 2021Article
- Article
- Molecular epidemiology and genome analysis of feline morbillivirus in household and shelter cats in Thailand.BMC veterinary research · 2020Article
- Feline Morbillivirus, a New Paramyxovirus Possibly Associated with Feline Kidney Disease.Viruses · 2020Review
- Epidemiology, pathological aspects and genome heterogeneity of feline morbillivirus in Italy.Veterinary microbiology · 2020Article
- Morbilliviruses: Entry, Exit and Everything In-Between.Viruses · 2019Article
- Molecular detection and characterisation of feline morbillivirus in domestic cats in Malaysia.Veterinary microbiology · 2019Article
- Feline morbillivirus in Northern Italy: prevalence in urine and kidneys with and without renal disease.Veterinary microbiology · 2019Article
- Feline morbillivirus infection associated with fatal encephalitis in a Bengal cat.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Paramyxoviruses comprise a large number of diverse viruses which in part give rise to severe diseases in affected hosts. A new genotype of feline morbillivirus, tentatively named feline morbillivirus genotype 2 (FeMV-GT2), was isolated from urine of cats with urinary tract diseases. Whole genome sequencing showed about 78% nucleotide homology to known feline morbilliviruses. The virus was isolated in permanent cell lines of feline and simian origin. To investigate the cell tropism of FeMV-GT2 feline primary epithelial cells from the kidney, the urinary bladder and the lung, peripheral blood mononuclear cells (PBMC), as well as organotypic brain slice cultures were used for infection experiments. We demonstrate that FeMV-GT2 is able to infect renal and pulmonary epithelial cells, primary cells from the cerebrum and cerebellum, as well as immune cells in the blood, especially CD4⁺ T cells, CD20⁺ B cells and monocytes. The cats used for virus isolation shed FeMV-GT2 continuously for several months despite the presence of neutralizing antibodies in the blood. Our results point towards the necessity of increased awareness for this virus when clinical signs of the aforementioned organs are encountered in cats which cannot be explained by other etiologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.