ArticleInternational journal of molecular sciences2019
Plasma Dimethylarginine Levels and Carotid Intima-Media Thickness are related to Atrial Fibrillation in Patients with Embolic Stroke.
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Symmetric Dimethylarginine for Risk Stratification of Cardioembolic Stroke.Translational stroke research · 2026Article
- SDMA as a marker and mediator in cerebrovascular disease.Clinical science (London, England : 1979) · 2024Review
- Developmental dynamics of homoarginine, ADMA and SDMA plasma levels from birth to adolescence.Amino acids · 2023Article
- Diagnostic value of carotid intima-media thickness and clinical risk scores in determining etiology of ischemic stroke.European stroke journal · 2023Article
- ADAMTS-13 activity in stroke of known and unknown cause: Relation to vascular risk factor burden.Frontiers in neurology · 2022Article
- Arginine Derivatives in Cerebrovascular Diseases: Mechanisms and Clinical Implications.International journal of molecular sciences · 2020Review
- Low homoarginine/SDMA ratio is associated with poor short- and long-term outcome after stroke in two prospective studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Markers of endothelial pathology to support detection of atrial fibrillation in embolic stroke of undetermined source.Scientific reports · 2019Article
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
A relevant part of embolic strokes of undetermined source (ESUS) is assumed to be due to non-detected atrial fibrillation (AF). In this study, we aimed to investigate if markers of endothelial dysfunction and damage may indicate AF risk in embolic stroke. Eighty-eight patients with ischemic stroke confirmed by imaging were assigned to one of three groups: ESUS, AF, or micro-/macroangiopathy. ESUS patients underwent prolonged Holter electrocardiography scheduled for three days. The National Institutes of Health Stroke Scale (NIHSS), the CHA₂DS₂VASC score, and the carotid intima⁻media thickness (CIMT) were obtained. Markers of endothelial (dys)function (L-arginine, asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA)) were measured at day seven after stroke. ESUS patients were younger and had fewer cardiovascular risk factors than patients with determined stroke etiology. Compared with AF patients, ESUS patients showed significantly lower values of SDMA (
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