ArticleNeuroImage. Clinical2019
White-matter pathways and semantic processing: intrasurgical and lesion-symptom mapping evidence.
Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- An update on tests used for intraoperative monitoring of cognition during awake craniotomy.Acta neurochirurgica · 2024Pooled it
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- Music and Affective Prosody after Surgical Removal of the Right Arcuate Fasciculus: A Case Study.Annals of the New York Academy of Sciences · 2025Article
- White matter correlates of language ability in chinese boys with autism spectrum disorder: a diffusional kurtosis imaging study.European journal of pediatrics · 2025Article
- Semantic Memory, Traumatic Brain Injury, and the Iceberg Effect: What Deficits May Lie Below the Surface?American journal of speech-language pathology · 2025Review
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- Networks for proper versus common name retrieval: insights from causal mapping and new hypotheses.Brain communications · 2025Review
- Brain local structural connectomes and the subtypes of the medial temporal lobe parcellations.Frontiers in neuroscience · 2025Article
- The role of language-related functional brain regions and white matter tracts in network plasticity of post-stroke aphasia.Journal of neurology · 2024Review
- Impact of white matter hyperintensities on structural connectivity and cognition in cognitively intact ADNI participants.Neurobiology of aging · 2024Article
- Ventral and dorsal aspects of the inferior frontal-occipital fasciculus support verbal semantic access and visually-guided behavioural control.Brain structure & function · 2024Article
- The central role of the left inferior longitudinal fasciculus in the face-name retrieval network.Human brain mapping · 2023Article
- A narrative review of the anatomy and function of the white matter tracts in language production and comprehension.Frontiers in human neuroscience · 2023Review
- Mapping lesion, structural disconnection, and functional disconnection to symptoms in semantic aphasia.Brain structure & function · 2022Article
- Neural network bases of thematic semantic processing in language production.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Article
- Time course of right-hemisphere recruitment during word production following left-hemisphere damage: A single case of young stroke.The European journal of neuroscience · 2022Article
- Comparing human and chimpanzee temporal lobe neuroanatomy reveals modifications to human language hubs beyond the frontotemporal arcuate fasciculus.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Inferior fronto-occipital fascicle displacement in temporoinsular gliomas using diffusion tensor imaging.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022Article
- Structural connectivity in ventral language pathways characterizes non-verbal autism.Brain structure & function · 2022Article
- The Use of Standardized Intraoperative Language Tests in Awake Craniotomies: A Scoping Review.Neuropsychology review · 2022Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, we aimed to test the association between the correct function of the left ventral white matter pathways and semantic processing (dual stream models for language processing, Hickok & Poeppel, 2004), using a new set of language tasks during intraoperative electrical stimulation at white matter level. Additionally, we evaluated brain regions needed for correct performance on the different semantic tasks using lesion-symptom analyses (voxel lesion-symptom mapping and track-wise lesion analysis) in a sample of 62 candidates for the awake brain surgery. We found that electrical stimulation in the vicinity of the inferior longitudinal and inferior fronto-occipital fasciculi disturbed performance on semantic processing tasks. Individuals presented with significantly more semantic paraphasias during brain tumor resection than during the electrical stimulation at the cortex level. Track-wise analyses confirmed the role of these left ventral pathways in semantic processing: a significant relationship was observed between the probability of inferior fronto-occipital fasciculus disconnection/damage and the semantic matching tasks, as well as the number of semantic paraphasias in naming. Importantly, the same analyses for the total score of the Boston Naming Test confirmed significant relationships between this test score and the integrity of the inferior fronto-occipital, inferior longitudinal and uncinate fasciculi. This was further supported by the results of VLSM analyses showing a significant relationship between BNT and the presence of lesion within left middle and inferior temporal gyri. The present findings provide new intraoperative evidence for the role of the white-matter ventral pathways in semantic processing, while at the same time emphasizing the need to include a broader assessment of semantic-conceptual aspects during the awake neurosurgical intervention. This approach will ensure better preservation of functional tissue in the tumoral vicinity and therefore substantially diminish post-surgical language impairments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.