ArticleJournal of affective disorders2019
Resting-state functional connectivity and inflexibility of daily emotions in major depression.
Article in Journal of affective disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Neuroscience meets behavior: A systematic literature review on magnetic resonance imaging of the brain combined with real-world digital phenotyping.Human brain mapping · 2024Pooled it
- Emotional stimulation processing characteristics in depression: Meta-analysis of eye tracking findings.Frontiers in psychology · 2022Pooled it
- Systematic Review of Functional MRI Applications for Psychiatric Disease Subtyping.Frontiers in psychiatry · 2021Pooled it
- Balancing act: Neural correlates of affect dysregulation in youth depression and substance use - A systematic review of functional neuroimaging studies.Developmental cognitive neuroscience · 2020Pooled it
- Reduced alpha power predicts recurrence risk in major depressive disorder.Neuroimage. Reports · 2026Article
- Brain-heart interactions in late-onset major depressive disorder revealed by multimodal HRV-driven fMRI.Communications biology · 2026Article
- Altered subgenual anterior cingulate cortex connectivity in psoriasis patients with depression: a resting-state fMRI case-control study.Annals of general psychiatry · 2026Article
- Neural substrates of affective temperaments: An intersubject representational similarity analysis to resting-state functional magnetic resonance imaging in nonclinical subjects.Human brain mapping · 2024Article
- Resting-state functional network segregation of the default mode network predicts valence bias across the lifespan.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- AI-based dimensional neuroimaging system for characterizing heterogeneity in brain structure and function in major depressive disorder: COORDINATE-MDD consortium design and rationale.BMC psychiatry · 2023Article
- Individual brain regulation as learned via neurofeedback is related to affective changes in adolescents with autism spectrum disorder.Child and adolescent psychiatry and mental health · 2023Article
- Neuroanatomy of post-stroke depression: the association between symptom clusters and lesion location.Brain communications · 2023Article
- Pain and the Triple Network Model.Frontiers in neurology · 2022Review
- Abnormal Dynamic Functional Network Connectivity Estimated from Default Mode Network Predicts Symptom Severity in Major Depressive Disorder.Brain connectivity · 2021Article
- Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder.Translational psychiatry · 2021Article
- Prognosis of C4 dislocation with spinal cord injury following psychological intervention.The Journal of international medical research · 2021Article
- Default mode and salience network alterations in suicidal and non-suicidal self-injurious thoughts and behaviors in adolescents with depression.Translational psychiatry · 2021Article
- Neuropeptide Y Variation Is Associated With Altered Static and Dynamic Functional Connectivity of the Salience Network.Frontiers in systems neuroscience · 2021Article
- Influences of affective context on amygdala functional connectivity during cognitive control from adolescence through adulthood.Developmental cognitive neuroscience · 2020Article
- Amplitude of Low-Frequency Oscillations in Major Depressive Disorder With Childhood Trauma.Frontiers in psychiatry · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundMajor Depressive Disorder (MDD) is characterized by aberrant resting-state functional connectivity (FC) in anterior cingulate regions (e.g., subgenual anterior cingulate [sgACC]) and by negative emotional functioning that is inflexible or resistant to change.
methodsMDD (N = 33) and control (CTL; N = 31) adults completed a resting-state scan, followed by a smartphone-based Experience Sampling Methodology (ESM) protocol surveying 10 positive and negative emotions 5 times per day for 21 days. We used multilevel modeling to assess moment-to-moment emotional inflexibility (i.e., strong temporal connections between emotions). We examined group differences in whole-brain FC analysis of bilateral sgACC, and then examined associations between emotional experiences and the extracted FC values within each group.
resultsAs predicted, MDDs had inflexibility in sadness and avoidance (p < .001, FDR-corrected p < .05), indicating that these emotional experiences persist in depression. MDDs showed weaker FC between the right sgACC and pregenual/dorsal anterior cingulate (pg/dACC) than did CTLs (FWE-corrected, voxelwise p = .01). Importantly, sgACC-pg/dACC FC predicted sadness inflexibility in both MDDs (p = .046) and CTLs (p = .033), suggesting that sgACC FC is associated with day-to-day negative emotions. LIMITATIONS: Other maladaptive behaviors likely also affect the flexibility of negative emotions. We cannot generalize our finding of a positive relation between sgACC FC and inflexibility of sadness to individuals with more chronic depression or who have recovered from depression.
conclusionsOur preliminary findings suggest that connections between portions of the ACC contribute to the persistence of negative emotions and are important in identifying a brain mechanism that may underlie the maintenance of sadness in daily life.
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