ArticleNeuroscience2019
Impaired cognitive flexibility following NMDAR-GluN2B deletion is associated with altered orbitofrontal-striatal function.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- GluN2A Enables Noradrenergic Control of Prefrontal Oscillations and Cognitive Flexibility.eNeuro · 2026Article
- CXCR2 immunomodulatory therapy protects against microstructural white matter injury and gait abnormalities but does not mitigate deficits of cognition in a preclinical model of cerebral palsy.Journal of neurochemistry · 2025Article
- Knockout of AMPA receptor binding protein Neuron-specific gene 2 (NSG2) enhances associative learning and cognitive flexibility.Molecular brain · 2024Article
- Knockout of AMPA receptor binding protein Neuron-Specific Gene 2 (NSG2) enhances associative learning and cognitive flexibility.Research square · 2024Article
- Optogenetic stimulation of corticostriatal circuits improves behavioral flexibility in mice with prenatal alcohol exposure.Neuropharmacology · 2024Article
- Dynamic regulation of corticostriatal glutamatergic synaptic expression during reversal learning in male mice.Neurobiology of learning and memory · 2024Article
- Regulation of neuronal circHomer1 biogenesis by PKA/CREB/ERK-mediated pathways and effects of glutamate and dopamine receptor blockade.Research square · 2024Article
- Gamma-Aminobutyric Acid and Glutamate Concentrations in the Striatum and Anterior Cingulate Cortex Not Found to Be Associated with Cognitive Flexibility.Brain sciences · 2023Article
- Open science and data sharing in cognitive neuroscience with MouseBytes and MouseBytes.Scientific data · 2023Article
- GluN2B-containing NMDARs in the mammalian brain: pharmacology, physiology, and pathology.Frontiers in molecular neuroscience · 2023Review
- Touchscreen cognitive deficits, hyperexcitability and hyperactivity in males and females using two models of Cdkl5 deficiency.Human molecular genetics · 2022Article
- A bidirectional competitive interaction between circHomer1 and Homer1b within the orbitofrontal cortex regulates reversal learning.Cell reports · 2022Article
- Sex-specific effect of prenatal alcohol exposure on N-methyl-D-aspartate receptor function in orbitofrontal cortex pyramidal neurons of mice.Alcoholism, clinical and experimental research · 2021Article
- Concurrent electrophysiological recording and cognitive testing in a rodent touchscreen environment.Scientific reports · 2021Article
- Chronic alcohol exposure during critical developmental periods differentially impacts persistence of deficits in cognitive flexibility and related circuitry.International review of neurobiology · 2021Review
- Dichotomic Hippocampal Transcriptome After Glutamatergic vs. GABAergic Deletion of the Cannabinoid CB1 Receptor.Frontiers in synaptic neuroscience · 2021Article
- A molecular insight into the dissociable regulation of associative learning and motivation by the synaptic protein neuroligin-1.BMC biology · 2020Article
- Glutamatergic and Serotonergic Modulation of Rat Medial and Lateral Orbitofrontal Cortex in Visual Serial Reversal Learning.Psychology & neuroscience · 2020Article
- Adolescent-onset vs. adult-onset cocaine use: Impact on cognitive functioning in animal models and opportunities for translation.Pharmacology, biochemistry, and behavior · 2020Review
- Dissociable and Paradoxical Roles of Rat Medial and Lateral Orbitofrontal Cortex in Visual Serial Reversal Learning.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Kristin MarquardtDepartment of Neurosciences, University of New, Mexico, School of Medicine, Albuquerque, NM.
Megan JoseyDepartment of Neurosciences, University of New, Mexico, School of Medicine, Albuquerque, NM.
Johnny A KentonDepartment of Neurosciences, University of New, Mexico, School of Medicine, Albuquerque, NM.
James F CavanaghDepartment of Psychology, University of New, Mexico.
Andrew HolmesLaboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.
Jonathan L BrigmanDepartment of Neurosciences, University of New, Mexico, School of Medicine, Albuquerque, NM; New, Mexico, Alcohol Research Center, UNM Health Sciences Center, Albuquerque, NM. Electronic address: jbrigman@salud.unm.edu.
National Institute on Alcohol Abuse and Alcoholism · US
Funding
TREATING ETHANOL WITHDRAWAL WITH LORAZEPAM/NALTREXONEP50AA010761 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Lisa M McTeague · 1996 to 2026
$46.8MUniversity of New Mexico (UNM) Center for Brain Recovery and RepairP20GM109089 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI MCKENZIE, SAMUEL ARNOLD · 2015 to 2024
$22.7MUnderstanding neurophysiological deficits in response inhibition in children with FASDP50AA022534 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Carlos Fernando Valenzuela · 2014 to 2026
$21.5MAlcohol Research Training in NeurosciencesT32AA014127 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Jonathan L Brigman · 2003 to 2026
$3.3MPrenatal alcohol exposure and corticostriatal mediation of behavioral flexibilityR01AA025652 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BRIGMAN, JONATHAN L · 2018 to 2022
$1.7MCorticostriatal networks and NMDAR mediation of habitual and flexible actionK22AA020303 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BRIGMAN, JONATHAN L · 2011 to 2013
$486kAltered neuronal dynamics of executive control after prenatal alcohol exposureF31AA025259 · NIAAA · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI MARQUARDT, KRISTIN LEE · 2016 to 2016
$44kNIAAA NIH HHS F31 AA025259NIAAA NIH HHS K22 AA020303NIAAA NIH HHS P50 AA010761NIAAA NIH HHS P50 AA022534NIAAA NIH HHS R01 AA025652NIAAA NIH HHS T32 AA014127NIGMS NIH HHS P20 GM109089
Abstract
A common feature across neuropsychiatric disorders is inability to discontinue an action or thought once it has become detrimental. Reversal learning, a hallmark of executive control, requires plasticity within cortical, striatal and limbic circuits and is highly sensitive to disruption of N-methyl-
Indexed as
AnimalsCognitive DysfunctionCorpus StriatumMaleMiceMice, Inbred C57BLMice, TransgenicPrefrontal CortexReceptors, N-Methyl-D-AspartateReversal LearningNR2B NMDA receptorReceptors, N-Methyl-D-Aspartateexecutive functionin vivo electrophysiologyNMDAR local field potentials
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.