Evidence map›Paper›PMID 30742844›Full record

ArticleMicrovascular research2019

Continuous monitoring of interstitial tissue oxygen using subcutaneous oxygen microsensors: In vivo characterization in healthy volunteers.

Stephen C Kanick, Peter A Schneider, Bruce Klitzman, Natalie A Wisniewski, Kerstin Rebrin

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Microvascular research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04514861 (Effectiveness of Measuring Local Tissue Oxygen in Response to Induced Hemodynamic Changes With the Profusa's Wireless Lumee Oxygen Platform in Patients With Peripheral Artery Disease), which is not on this map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04514861 naactive not recruitingnot on this mapstarted 2020, after this paper: background citation

Effectiveness of Measuring Local Tissue Oxygen in Response to Induced Hemodynamic Changes With the Profusa's Wireless Lumee Oxygen Platform in Patients With Peripheral Artery Disease (PAD)

TypeinterventionalSponsorProfusa, Inc.Ran2020 to 2028Enrolled53ConditionsPeripheral Artery DiseaseArmsWireless Lumee Oxygen Platform
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 49 citations in OpenAlex.

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  20. Vasomotion analysis of speed resolved perfusion, oxygen saturation, red blood cell tissue fraction, and vessel diameter: Novel microvascular perspectives.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Stephen C KanickProfusa Inc., South San Francisco, CA, USA. Electronic address: stephen.kanick@profusa.com.
Peter A SchneiderKaiser Permanente Medical Center, Honolulu, HI, USA.
Bruce KlitzmanKenan Plastic Surgery Research Labs and Biomedical Engineering, Duke University, Durham, NC, USA.
Natalie A WisniewskiProfusa Inc., South San Francisco, CA, USA.
Kerstin RebrinProfusa Inc., South San Francisco, CA, USA.
Profusa (United States) · USDuke University · USKaiser Permanente · US

Funding

Implantable multi-analyte sensors for the continuous monitoring of body chemistriR01EB016414 · NIBIB · PROFUSA, INC. · PI MCSHANE, MIKE, WISNIEWSKI, NATALIE ANN · 2012 to 2015
$4.9M
Real-Time Oxygen Monitoring for Tissue Health: Peripheral Artery Disease ApplicationR42HL127933 · NHLBI · PROFUSA, INC. · PI NICHOLS, SCOTT · 2015 to 2017
$2.0M
Tissue Oxygen Monitoring in Peripheral Vascular DiseaseR44HL131366 · NHLBI · PROFUSA, INC. · PI CONTE, MICHAEL S, REBRIN, KERSTIN · 2016 to 2019
$1.7M
NHLBI NIH HHS R42 HL127933NHLBI NIH HHS R44 HL131366NIBIB NIH HHS R01 EB016414
6 · The paper itself

Abstract

Measurements of regional tissue oxygen serve as a proxy to monitor local perfusion and have the potential to guide therapeutic decisions in multiple clinical disciplines. Transcutaneous oximetry (tcpO

Indexed as

TransducersAdultAgedArteriesBiosensing TechniquesBlood Gas Monitoring, TranscutaneousEquipment DesignFeasibility StudiesFemaleHealthy VolunteersHumansMaleMiddle AgedMiniaturizationOxygenPredictive Value of TestsOxygenMedical deviceMicrocirculationPerfusion monitoringSubcutaneous oxygen microsensorsTranscutaneous tissue oximetryVascular occlusion

Identifiers

PMID30742844
PMCPMC6570499
OpenAlexW2914522524

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.