Evidence map›Paper›PMID 30742739›Full record

ArticleChembiochem : a European journal of chemical biology2019

Cross-Isotopic Bioorthogonal Tools as Molecular Twins for Radiotheranostic Applications.

Veronika Rosecker, Christoph Denk, Melanie Maurer, Martin Wilkovitsch, Severin Mairinger, Thomas Wanek, Hannes Mikula

Abstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Cross-Isotopic Bioorthogonal Tools as Molecular Twins for Radiotheranostic Applications.Chembiochem : a European journal of chemical biology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Veronika RoseckerInstitute of Applied Synthetic Chemistry, TU Wien (Vienna University of Technology), Getreidemarkt 9, 1060, Vienna, Austria.
Christoph DenkInstitute of Applied Synthetic Chemistry, TU Wien (Vienna University of Technology), Getreidemarkt 9, 1060, Vienna, Austria.
Melanie MaurerInstitute of Applied Synthetic Chemistry, TU Wien (Vienna University of Technology), Getreidemarkt 9, 1060, Vienna, Austria.
Martin WilkovitschInstitute of Applied Synthetic Chemistry, TU Wien (Vienna University of Technology), Getreidemarkt 9, 1060, Vienna, Austria.
Severin MairingerPreclinical Molecular Imaging, AIT Austrian Institute of Technology, 2444, Seibersdorf, Austria.
Thomas WanekPreclinical Molecular Imaging, AIT Austrian Institute of Technology, 2444, Seibersdorf, Austria.
Hannes MikulaInstitute of Applied Synthetic Chemistry, TU Wien (Vienna University of Technology), Getreidemarkt 9, 1060, Vienna, Austria.ORCID 0000-0002-9218-9722

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiotheranostics are designed by labeling targeting (bio)molecules with radionuclides for diagnostic or therapeutic application. Because the pharmacokinetics of therapeutic compounds play a pivotal role, chemically closely related imaging agents are used to evaluate the overall feasibility of the therapeutic approach. "Theranostic relatives" that utilize different elements are frequently used in clinical practice. However, variations in pharmacokinetics, biodistribution, and target affinity due to different chemical properties of the radioisotopes remain as hurdles to the design of optimized clinical tools. Herein, the design and synthesis of structurally identical compounds, either for diagnostic (

Indexed as

RadiopharmaceuticalsClick ChemistryHumansIsotope LabelingTheranostic NanomedicineTissue DistributionRadiopharmaceuticalsbioorthogonal chemistryclick chemistryisotopesradiochemistryradiopharmaceuticals

Identifiers

PMID30742739
PMCPMC6617999

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.