ArticlePloS one2019
Postoperative respiratory failure in liver transplantation: Risk factors and effect on prognosis.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Effect of neurally adjusted ventilator assist versus pressure support ventilation on asynchronies and cardiac function in pediatric liver transplantation.Scientific reports · 2025Trial
- Laryngeal mask airway use during liver transplantation: perioperative outcomes in a propensity score-matched cohort.Annals of medicine · 2026Article
- Tracheostomy after living donor liver transplantation: the incidence, risk factors, and prognostic significance.Surgery today · 2026Article
- Impact of postoperative pulmonary complications on clinical outcomes in liver transplantation: a single-center retrospective analysis.BMC pulmonary medicine · 2026Article
- Excessive Intraoperative Blood Loss Increases the Risk of Postoperative Complications After Liver Transplantation: A Retrospective Multicenter Study.Annals of transplantation · 2026Article
- Observational
- Clinical predictors of extubation failure in postoperative critically ill patients: a post-hoc analysis of a multicenter prospective observational study.BMC anesthesiology · 2025Observational
- The effects of venovenous bypass use in liver transplantation with piggyback technique: a propensity score-weighted analysis.Internal and emergency medicine · 2024Observational
- Fluid Responsiveness Is Associated with Successful Weaning after Liver Transplant Surgery.Journal of personalized medicine · 2024Article
- Intensive Care Unit-Acquired Weakness after Liver Transplantation: Analysis of Seven Cases and a Literature Review.Journal of clinical medicine · 2023Review
- Factors associated with mechanical ventilation longer than 24 h after liver transplantation in patients at risk for bleeding.BMC anesthesiology · 2023Article
- Challenges in Diagnosis and Therapeutic Approach of Acute on Chronic Liver Failure-A Review of Current Evidence.Biomedicines · 2023Review
- Expert consensus on liver transplantation perioperative evaluation and rehabilitation for acute-on-chronic liver failure.Liver research (Beijing, China) · 2022Article
- Association between surgical volumes and hospital mortality in patients: a living donor liver transplantation single center experience.BMC gastroenterology · 2021Article
- Solid Organ Transplantation During COVID-19 Pandemic: An International Web-based Survey on Resources' Allocation.Transplantation direct · 2021Article
- Development and Validation of a Comprehensive Model to Estimate Early Allograft Failure Among Patients Requiring Early Liver Retransplant.JAMA surgery · 2020Article
- Preoperative risk factors for massive transfusion, prolonged ventilation requirements, and mortality in patients undergoing liver transplantation.Korean journal of anesthesiology · 2020Observational
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostoperative respiratory failure (PRF, namely mechanical ventilation >48 hours) significantly affects morbidity and mortality in liver transplantation (LTx). Previous studies analyzed only one or two categories of PRF risk factors (preoperative, intraoperative or postoperative ones). The aims of this study were to identify PRF predictors, to assess the length of stay (LoS) in ICU and the 90-day survival according to the PRF in LTx patients.
methodsTwo classification approaches were used: systematic classification (recipient-related preoperative factors; intraoperative factors; logistic factors; donor factors; postoperative ICU factors; postoperative surgical factors) and patient/organ classification (patient-related general factors; native-liver factors; new-liver factors; kidney factors; heart factors; brain factors; lung factors). Two hundred adult non-acute patients were included. Missing analysis was performed. The competitive role of each factor was assessed.
resultsPRF occurred in 36.0% of cases. Among 28 significant PRF predictors at univariate analysis, 6 were excluded because of collinearity, 22 were investigated by ROC curves and by logistic regression analysis. Recipient age (OR = 1.05; p = 0.010), female sex (OR = 2.75; p = 0.018), Model for End-Stage Liver Disease (MELD, OR = 1.09; p<0.001), restrictive lung pattern (OR = 2.49; p = 0.027), intraoperative veno-venous bypass (VVBP, OR = 3.03; p = 0.008), pre-extubation PaCO2 (OR = 1.11; p = 0.003) and Model for Early Allograft Function (MEAF, OR = 1.37; p<0.001) resulted independent PRF risk factors. As compared to patients without PRF, the PRF-group had longer LoS (10 days IQR 7-18 versus 5 days IQR 4-7, respectively; p<0.001) and lower day-90 survival (86.0% versus 97.6% respectively, p<0.001).
conclusionIn conclusion, MELD, restrictive lung pattern, surgical complexity as captured by VVBP, pre-extubation PaCO2 and MEAF are the main predictors of PRF in non-acute LTx patients.
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