ArticlePloS one2019
Difficulty of predicting lymph node metastasis on CT in patients with rectal neuroendocrine tumors.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Risk factors for lateral pelvic lymph node metastasis in patients with rectal neuroendocrine tumors: a systematic review and meta-analysis.Frontiers in oncology · 2025Pooled it
- Tumor count and risk of lymph node metastasis in multiple rectal neuroendocrine tumors: an individual-level pooled analysis.World journal of surgical oncology · 2026Article
- Rectal neuroendocrine tumors: Update.World journal of gastrointestinal oncology · 2026Review
- Predicting Lymph Node Metastasis in Rectal Cancer: Development and Validation of a Machine Learning Model Using Clinical Data.JMIR medical informatics · 2025Article
- Current advances in neuroendocrine neoplasms of the colon and rectum.World journal of clinical oncology · 2025Review
- Recurrence pattern and mapping of lymph node metastases from rectal neuroendocrine tumors.International journal of colorectal disease · 2025Article
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- Article
- Risk Factors for Lymph Node Metastasis of Rectal Neuroendocrine Tumor and Its Prognostic Impact: A Single-Center Retrospective Analysis of 195 Cases with Radical Resection.Annals of surgical oncology · 2023Article
- Rectal neuroendocrine neoplasms: what the radiologists should know.Abdominal radiology (New York) · 2022Review
- A small, low-grade rectal neuroendocrine tumor with lateral pelvic lymph node metastasis: a case report.Annals of coloproctology · 2022Article
- Rectal Neuroendocrine Neoplasms: Why Is There a Global Variation?Current oncology reports · 2022Review
- Case report: Indocyanine green fluorescence-guided imaging in laparoscope, a more sensitive detection technique of lateral lymph nodes metastases from rectal neuroendocrine tumors.Frontiers in oncology · 2022Article
- Indications for lateral lymph node dissection in patients with rectal neuroendocrine tumors: A case report and review of the literature.Molecular and clinical oncology · 2021Article
- A nationwide, multi-institutional collaborative retrospective study of colorectal neuroendocrine tumors in Japan.Annals of gastroenterological surgery · 2021Article
- Prediction of the World Health Organization Grade of rectal neuroendocrine tumors based on CT histogram analysis.Cancer medicine · 2021Article
- Rectal neuroendocrine tumor developing lateral lymph node metastasis after curative resection: a case report.World journal of surgical oncology · 2020Article
- Reference intervals of mesenteric lymph node size according to lymphocyte counts in asymptomatic children.PloS one · 2020Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurgical indications for rectal neuroendocrine tumors with potential lymph node metastasis remain controversial. Although accurate preoperative diagnosis of nodal status may be helpful for treatment strategy, scant data about clinical values of lymph node size have been reported. The aim of this retrospective study was to investigate the relationship between lymph node size and lymph node metastasis.
methodsParticipants comprised 102 patients who underwent rectal resection with total mesenteric excision or tumor-specific mesenteric excision and in some cases additional lateral pelvic lymph node dissection for rectal neuroendocrine tumor between June 2005 and September 2016. All lymph nodes from specimens were checked and measured.
resultsPathological lymph node metastasis was confirmed in 37 patients (36%), including 6 patients (5.8%) with lateral pelvic lymph node metastasis. A total of 1169 lymph nodes in the mesorectum were retrieved from all specimens, with 78 lymph nodes (6.7%) showing metastasis. Mean length (long-axis diameter) of metastatic lymph nodes in the mesorectum was 4.31 mm, significantly larger than that of non-metastatic lymph nodes (2.39 mm, P<0.01). The optimal cut-off of major axis length for predicting mesorectal lymph node metastasis was 3 mm. We could predict lymph node metastasis in only 7 patients (21%) from preoperative multidetector-row computed tomography.
conclusionsMetastatic lymph nodes were small, so predicting lymph node metastasis from preoperative computed tomography is difficult. Alternative modalities with a scan width less than 3 mm may be needed to predict lymph node metastasis of rectal NET with low cost and labour requirements.
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