Evidence map›Paper›PMID 30742638›Full record

ArticlePloS one2019

Correlation between macrophage migration inhibitory factor and autophagy in Helicobacter pylori-associated gastric carcinogenesis.

Kichul Yoon, Nayoung Kim, Youngmi Park, Bo Kyung Kim, Ji Hyun Park, Cheol Min Shin, Dong Ho Lee, Young-Joon Surh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kichul YoonDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
Nayoung KimDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.ORCID 0000-0002-9397-0406
Youngmi ParkMedical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, South Korea.
Bo Kyung KimDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
Ji Hyun ParkDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
Cheol Min ShinDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
Dong Ho LeeDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
Young-Joon SurhTumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul, South Korea.
Seoul National University · KRSeoul National University Bundang Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of macrophage migration inhibitory factor (MIF) and autophagy in gastric cancer is not clear. We determined H. pylori infection status of the subjects and investigated the expression of MIF and autophagy markers (Atg5, LC3A and LC3B) in human gastric tissue at baseline. Then H. pylori eradication was done for H. pylori positive patients and MIF and Atg5 levels were investigated on each follow-up for both H. pylori-eradicated and H. pylori negative patients. Baseline tissue mRNA expression of MIF, Atg5, LC3A and LC3B was measured by real-time PCR in 453 patients (control 165, gastric dysplasia 82, and gastric cancer 206). Three hundred three patients (66.9%) had H. pylori infection at the time of enrollment. Only within H. pylori-positive group, MIF level was significantly elevated in patients with cancer than in control or dysplasia groups (P<0.05). LC3A and LC3B levels also showed significant differences within H. pylori-positive subgroups. H. pylori-positive dysplasia subgroup showed significantly lower (LC3A) (P<0.05) and higher (LC3B) mRNA levels (P<0.05) than in other subgroups. On follow-up, within H. pylori-eradicated group, Atg5 expression increased sequentially from control to dysplasia and cancer subgroups. Multiple linear regression showed autophagy markers (LC3A, LC3B, and Atg5) directly predicted MIF level (adjusted R2 = 0.492, P<0.001). Serial follow-up showed longitudinal increase in Atg5 level in general, with constantly higher levels in H. pylori-eradicated group than in -negative group. Intestinal metaplasia (IM) group initially showed higher Atg5 expression than the IM-negative group. However, it was reversed between the groups eventually because of the lower rate of increase in IM group. These results suggest a role of MIF and autophagy markers and their interaction in H. pylori-associated gastric carcinogenesis.

Indexed as

AutophagyCarcinogenesisHelicobacter pyloriCase-Control StudiesFemaleGastric MucosaHelicobacter InfectionsHumansIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMaleMicrotubule-Associated ProteinsMiddle AgedReal-Time Polymerase Chain ReactionStomach NeoplasmsIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMAP1LC3A protein, humanMAP1LC3B protein, humanMicrotubule-Associated ProteinsMIF protein, human

Identifiers

PMID30742638
PMCPMC6370197
OpenAlexW2912466573

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.