ArticlePLoS genetics2019
The CIN-TCP transcription factors promote commitment to differentiation in Arabidopsis leaf pavement cells via both auxin-dependent and independent pathways.
Article in PLoS genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A multiscale growth atlas of Arabidopsis: linking cell dynamics to organ development.The New phytologist · 2026Pooled it
- Growth-rate coordination across the width of a leaf preserves its flatness.PLoS biology · 2026Article
- A group of TCP transcription factors is a missing link in strigolactone signaling.Journal of integrative plant biology · 2026Article
- Progressive oxygenation of developing leaves directs morphogenesis.Science advances · 2026Article
- Molecular regulation of plant endoreduplication: core mechanisms and their upstream control.Plant molecular biology · 2026Review
- Genome-wide characterization of the TCP family in Lagerstroemia and functional analysis of LfiTCP12 uncover its role in shoot branching promotion.Plant cell reports · 2026Article
- Jujube Witches' Broom Phytoplasma Effectors SJP1/2 Manipulate the ZjTCP2-ZjTCP1 Cascade to Repress Leaf Cell Proliferation in Jujube.Molecular plant pathology · 2026Article
- Integrated single-nucleus transcriptomic and metabolomic insights into bud-to-leaf development and metabolite synthesis in tea plant.Horticulture research · 2026Article
- TCP3-mediated regulation of cell expansion in Arabidopsis thaliana.The New phytologist · 2025Article
- Genome-Wide Identification of thePlants (Basel, Switzerland) · 2025Article
- Identification of quantitative trait loci for in vitro plant regeneration from leaf microexplants in cucumber (Cucumis sativus L.).Journal of applied genetics · 2025Article
- JAG modulates sepal flatness by regulating cell growth direction, interacts with AS2, and is antagonized by TCP24.Cell reports · 2025Article
- Canalization of flower production across thermal environments requires Florigen and CLAVATA signaling.Current biology : CB · 2025Article
- Transcriptomic analysis of wrinkled leaf development of Tai-cai (Brassica rapa var. tai-tsai) and its synthetic allotetraploid via RNA and miRNA sequencing.Plant molecular biology · 2025Article
- The CIN-TCP transcription factors regulate endocycle progression and pavement cell size by promoting cell wall pectin degradation.Nature communications · 2025Article
- Genetic mapping and transcriptome profiling revealed leaf lobe formation and leaf size are regulated by GhRlTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Modulation of cell differentiation and growth underlies the shift from bud protection to light capture in cauline leaves.Plant physiology · 2024Article
- The Ins and Outs of Homeodomain-Leucine Zipper/Hormone Networks in the Regulation of Plant Development.International journal of molecular sciences · 2024Review
- Expression of the Arabidopsis redox-related LEA protein, SAG21 is regulated by ERF, NAC and WRKY transcription factors.Scientific reports · 2024Article
- A double-negative feedback loop between miR319c and JAW-TCPs establishes growth pattern in incipient leaf primordia in Arabidopsis thaliana.PLoS genetics · 2023Article
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3 authors.
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Abstract
Cells in organ primordia undergo active proliferation at an early stage to generate sufficient number, before exiting proliferation and entering differentiation. However, how the actively proliferating cells are developmentally reprogrammed to acquire differentiation potential during organ maturation is unclear. Here, we induced a microRNA-resistant form of TCP4 at various developmental stages of Arabidopsis leaf primordium that lacked the activity of TCP4 and its homologues and followed its effect on growth kinematics. By combining this with spatio-temporal gene expression analysis, we show that TCP4 commits leaf cells within the transition zone to exit proliferation and enter differentiation. A 24-hour pulse of TCP4 activity was sufficient to impart irreversible differentiation competence to the actively dividing cells. A combination of biochemical and genetic analyses revealed that TCP4 imparts differentiation competence by promoting auxin response as well as by directly activating HAT2, a HD-ZIP II transcription factor-encoding gene that also acts downstream to auxin response. Our study offers a molecular link between the two major organ maturation factors, CIN-like TCPs and HD-ZIP II transcription factors and explains how TCP activity restricts the cell number and final size in a leaf.
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