Evidence map›Paper›PMID 30742002›Full record

ArticleScientific reports2019

Molecular layer interneurons shape the spike activity of cerebellar Purkinje cells.

Amanda M Brown, Marife Arancillo, Tao Lin, Daniel R Catt, Joy Zhou, Elizabeth P Lackey, Trace L Stay, Zhongyuan Zuo, Joshua J White, Roy V Sillitoe

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 118 citations in OpenAlex.

  1. Review
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  8. Coordination of spike timing among the neurons of the cerebellum.bioRxiv : the preprint server for biology · 2025
    Article
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  12. Review
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  14. Review
  15. Article
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  18. Article
  19. Review
  20. Purkinje cell models: past, present and future.Frontiers in computational neuroscience · 2024
    Review

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Amanda M BrownDepartment of Pathology and Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA.
Marife ArancilloDepartment of Pathology and Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA.
Tao LinDepartment of Pathology and Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA.
Daniel R CattDepartment of Pathology and Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA.
Joy ZhouDepartment of Pathology and Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA.
Elizabeth P LackeyDepartment of Pathology and Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA.
Trace L StayDepartment of Pathology and Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA.
Zhongyuan ZuoDepartment of Pathology and Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA.
Joshua J WhiteDepartment of Pathology and Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA.
Roy V SillitoeDepartment of Pathology and Immunology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas, 77030, USA. sillitoe@bcm.edu.
Baylor College of Medicine · US

Funding

NRI Build-out: Advancing Translational Brain ResearchC06RR029965 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI ZOGHBI, HUDA Y · 2010 to 2010
$14.9M
Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8M
CEREBELLAR FUNCTION IN TREMORR01NS100874 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SILLITOE, ROY VINCENT · 2017 to 2021
$1.9M
SYNAPTIC ORIGINS OF CEREBELLAR DISEASER01NS089664 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SILLITOE, ROY VINCENT · 2014 to 2018
$1.7M
The role of cerebellar activity in tremor propagationF31NS101891 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI BROWN, AMANDA MICHELLE · 2017 to 2019
$134k
Cerebellar computations for sensing self-motionF31NS095491 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI STAY, TRACE LAMAR · 2015 to 2018
$132k
Cerebellar Function in DystoniaF31NS092264 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI WHITE, JOSHUA J · 2015 to 2016
$69k
NCRR NIH HHS C06 RR029965NICHD NIH HHS U54 HD083092NINDS NIH HHS F31 NS092264NINDS NIH HHS F31 NS095491NINDS NIH HHS F31 NS101891NINDS NIH HHS R01 NS089664NINDS NIH HHS R01 NS100874
6 · The paper itself

Abstract

Purkinje cells receive synaptic input from several classes of interneurons. Here, we address the roles of inhibitory molecular layer interneurons in establishing Purkinje cell function in vivo. Using conditional genetics approaches in mice, we compare how the lack of stellate cell versus basket cell GABAergic neurotransmission sculpts the firing properties of Purkinje cells. We take advantage of an inducible Ascl1

Indexed as

Action PotentialsAnimalsBasic Helix-Loop-Helix ProteinsBiomarkersgamma-Aminobutyric AcidImmunohistochemistryInterneuronsMiceNerve DegenerationPurkinje CellsVesicular Inhibitory Amino Acid Transport ProteinsAscl1 protein, mouseBasic Helix-Loop-Helix ProteinsBiomarkersgamma-Aminobutyric Acidvesicular GABA transporterVesicular Inhibitory Amino Acid Transport Proteins

Identifiers

PMID30742002
PMCPMC6370775
OpenAlexW2949691888

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.