ArticleScientific reports2019
The structural characterization of a polysaccharide exhibiting antitumor effect from Pholiota adiposa mycelia.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Purification, Structural Characteristics of Polysaccharides from Pholiota squarrosoides (Peck) Sacc and Their Hepatoprotective Effects on Alcohol-induced Liver Disease in Mice.Applied biochemistry and biotechnology · 2026Article
- Optimization of Liquid Culture of Extracellular Flavonoids ofFoods (Basel, Switzerland) · 2026Article
- The Domestication and Cultivation ofFoods (Basel, Switzerland) · 2025Article
- Integrated gut microbiota and metabolomics analysis reveals the antitumor effects of ergosta-4,6,8(14),22-tetraen-3-one purified from the medicinal fungus pholiota adiposa in tumor-bearing mice.Frontiers in pharmacology · 2025Article
- Anionic extracellular polymeric substances extracted from seawater-adapted aerobic granular sludge.Applied microbiology and biotechnology · 2024Article
- Optimization of Plasma Activated Water Extraction ofFoods (Basel, Switzerland) · 2023Article
- The effects of zinc sulfate on mycelial enzyme activity and metabolites of Pholiota adiposa.PloS one · 2023Article
- Extraction, physicochemical properties, and antioxidant activity of natural melanin fromFrontiers in nutrition · 2023Article
- Influence of Pholiota adiposa on gut microbiota and promote tumor cell apoptosis properties in H22 tumor-bearing mice.Scientific reports · 2022Article
- Optimization for the production of a polyketoneMycology · 2022Article
- Article
- Applications of infrared spectroscopy in polysaccharide structural analysis: Progress, challenge and perspective.Food chemistry: X · 2021Article
- Chemical characterization ofRSC advances · 2021Article
- Hepatoprotective effect of crude polysaccharides extracted fromVeterinary world · 2019Article
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4 authors.
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Abstract
PAP80-2a, purified from Pholiota adiposa mycelia, is a polysaccharide exhibiting prominent antitumor effects. However, the yield of PAP80-2a was low and its structure has not been characterized, impeding the exploration of its structure-function relationship, thus influencing the development of oral drugs for antitumor therapy and immunomodulation. In order to improve the yield of PAP80-2a, response surface methodology along with Box-Behnken design was applied to optimize the ultrasonic-assisted extraction conditions for polysaccharides. Then, the structure of PAP80-2a exhibiting antitumor activity was determined from different angles. The results showed that the extraction yield of P. adiposa polysaccharides increased by 11.5% under optimized ultrasonic extraction conditions. Structural analysis showed that PAP80-2a was mainly composed of glucose, rhamnose, xylose, and galactose in a ratio of 10.00: 2.09: 4.09: 1.13. The total amino acid content in the sugar chain was 69.92 μg/mL. The sugar chain structure was [α-Rha (1 → 3)-]n, and rhamnose was located at the non-reducing end of the sugar chain, while glucose was located at the non-reducing end or in the sugar chain in 1,2,6- and 1,3,6-linked forms. Our study clearly illuminates the primary structure of PAP80-2a, but 3D structure of PAP80-2a and its structure-function relationship is a future challenge.
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